Methods of Stimulating Proliferation and Differentiation of Human Pancreatic Cells Ex Vivo
Description of Invention:
These patents and applications generally relate to methods which may be used in treating diabetes. In particular, they describe methods for culturing pancreatic islet cells which will later be transplanted into patients. The culture of the pancreatic islet cells is carried out in the presence of hepatocyte growth factor/scatter factor (HGF/SF) under conditions such that differentiation and/or proliferation of the pancreatic islet cells occurs and insulin production is stimulated or increased. These insulin-producing pancreatic islet cells can then be transplanted into patients having diabetes mellitus (Type I diabetes).
Patent Status:
DHHS Reference No. E-045-1994/0 --
U.S. Patent 5,857,309 issued 24 Dec 1996
DHHS Reference No. E-045-1994/1 --
U.S. Patent 5,888,705 issued 30 Mar 1999
Relevant Publication:
T Otonkoski et al. Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells. Diabetes 1994 Jul;43(7):947-953 [PubMed abs]
A Hayek et al. Growth factor/matrix-induced proliferation of human adult beta-cells. Diabetes 1995 Dec;44(12):1458-1460. [PubMed abs]
T Otonkoski et al. A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Endocrinology 1996 Jul;137(7):3131-3139. [PubMed abs]
GM Beattie et al. Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact. Diabetes 1996 Sep;45(9):1223-1228. [PubMed abs]
For Additional Information Please Contact: Susan S. Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-4478
Email: ruckersu@mail.nih.gov
Fax: (301) 402-0220
