Description of Invention:
Motion artifacts continue to be a significant problem in MRI of human brain. Prospective motion correction based on external tracking systems has been proposed to ameliorate this issue. However, the calibration of these systems is very complicated and time consuming, as it requires a camera system calibration as well as a calibration between camera and MRI system using dedicated phantoms. An alternative motion correction method for MRI that does not require calibration and can work with just a single video camera has been developed and is available for licensing. This technology can be broadly applied in MRI to account for motion artifacts in order to improve acquisition time and provide enhanced resolution. This technique will provide a needed method to obtain reliable MRI scans for uncooperative patients (children, seizure patients, etc.) without the need and expense of multiple scans.
JH Duyn, P van Gelderen, TQ Li, JA de Zwart, AP Koretsky, M Fukunaga. High-field MRI of brain cortical substructure based on signal phase. Proc Natl Acad Sci USA. 2007 Jul 10;104(28):11796-17801. [PubMed abs]
TQ Li, P van Gelderen, H Merkle, L Talagala, AP Koretsky, J Duyn. Extensive heterogeneity in white matter intensity in high-resolution T2*-weighted MRI of the human brain at 7.0 T. Neuroimage. 2006 Sep;32(3):1032-1040. [PubMed abs]
Licensing Status: Available for licensing.
Collaborative Research Opportunity:
The National Institute of Neurological Disorders and Stroke - Advanced MRI Section - Laboratory of Functional and Molecular Imaging is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize MRI methods to improve data collection by improved homogeneity, resolution, etc. Please contact Dr. Melissa Maderia at 301-451-3943 or maderiam@mail.nih.gov for more information.
For Additional Information Please Contact: John Stansberry Ph.D.
NIH Office of Technology Transfer
6011 Executive Boulevard, Suite 325
Rockville, MD 20852-3804
Phone: (301)435-5236
Email: stansbej@mail.nih.gov
Fax: (301) 402-0220
