Novel Fluorinated Dmt-Tic Analogues for Use as PET Radiotracers
Description of Invention:
Researchers at the NIH have developed fluorine-18 (18F) labeled analogues specific for the delta- opioid receptors. These radioligands include analogues of the Dmt-Tic pharmacophore, containing a delta-opioid receptor antagonist that may be useful for imaging opioid receptors expressed in lung malignant tumors or other peripheral tumors that express delta-opioid receptors. This methodology might be readily applicable to Dmt-Tic pharmacophoric ligands that exhibit dual antagonism for delta-/mu-opioid receptors.
Studies by the inventors have shown that injected radioligand failed to cross the blood-brain barrier (BBB) of rats; therefore, these compounds could serve as radiotracers for assessing and locating certain carcinomas that contain high levels of delta-opioid receptors, such as lung, breast and/or colon cancers. Since there is an increasing demand of radioligands for in vivo imaging of peripheral opioid receptors, this technology has the potential of enhancing current practices of PET imaging in oncology.
Available for licensing are compositions and methods of locating delta- and/or mu-opioid receptors located in peripheral cancers, such as in lung, breast, and/or colorectal cancer, using opiate radioligands.
Applications:
Non-invasive tool for screening lung, breast, and/or colorectal cancers
Diagnostic tool for use in PET imaging
Market:
For 2007, it was projected that close to 1.5 million Americans would develop cancer.
PET imaging is steadily becoming a technique of choice in oncology so many of these patients will likely undergo scans several times during their treatment to assess the stage of their disease. This is supported by rising sales of FDG, which are expected to reach $933 million by 2012.
Relevant Publication: KA Roth and JD Barchas. Small cell carcinoma cell lines contain opioid peptides and receptors. Cancer 1986 Feb 15;57(4):769-773. [PubMed abs]
Licensing Status: Available for licensing
Collaborative Research Opportunity:
The NIEHS Laboratory of Pharmacology, Medicinal Chemistry Group, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology. Please contact Elizabeth Denholm, Ph.D., Director, NIEHS Office of Technology Transfer, at 919-541-0981 or denholme@mail.nih.gov for more information.
Portfolios: Internal Medicine Cancer
Cancer -Diagnostics-In Vivo-Other Internal Medicine-Diagnostics-Imaging-Agents Cancer -Diagnostics Internal Medicine-Diagnostics
For Additional Information Please Contact: Charlene A. Sydnor Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: 301/435-4689
Email: sydnorc@mail.nih.gov
Fax: 301/402-0220
