Tri-functional Imaging Agent for Monoclonal Antibody Tumor-Targeted Imaging
Description of Invention:
Available for licensing and commercial development is a novel lysine-based trifunctional chelate which bears both a chelating moiety (CHX-A") for sequestering radiometals (86Y or 111In) and a near-infrared dye, e.g., Cy5.5, for dual modality PET (or SPECT) and fluorescence imaging. Successful conjugation of monoclonal antibody trastuzumab (Herceptin) or cetuximab (Erbitux), has also been achieved by efficient thiol-maleimide chemistry, thereby yielding an immunoconjugate (Signaling agent (Cy5.5-Lys(SMCC)-CHX-A") conjugated to trastuzumab) or (Signaling agent (Cy7-Lys(SMCC)-CHX-A") conjugated to cetuximab). Both specifically target antigen expressing cells and internalization of the agent has been imaged over time. Trastuzumab can be radiolabeled with isothiocyanate derivatives of the bifunctional chelating agents 1B4M (2-(4-aminobenzy1)-6-methyldiethylenetriaminepentaacetic acid); and CHX-A" (N-[(R)-2-amino-3-(p-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N",N"-pentaacetic acid).
Relevant Publication: H Xu et al. Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging. J Med Chem. 2007 Sep 20;50(19):4759-4765. [PubMed abs]
Licensing Status: Available for licensing.
Collaborative Research Opportunity:
The National Cancer Institute Radiation Oncology Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, Trifunctional Imaging Agent for Monoclonal Antibody Tumor-Targeted Imaging. Please contact John D. Hewes, Ph.D. at 301-435-3121 or hewesj@mail.nih.gov for more information.
Portfolios: Devices/Instrumentation Cancer
Cancer -Diagnostics-In Vivo-MAb Cancer -Diagnostics-In Vivo-Conjugate Chemistry Cancer -Diagnostics-In Vivo-Other Devices/Instrumentation-Diagnostics-Imaging-Other Cancer -Diagnostics Devices/Instrumentation-Diagnostics
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
Fax: (301) 402-0220
