Usage of Two Yeast Strains in the Identification of Specific Inhibitors of Polo Kinases
Description of Invention:
This technology relates to the usage of two yeast strains in the identification of specific inhibitors of polo kinases. Polo kinases are characterized by the presence of a distinct region of homology in the non-catalytic C-terminal domain termed the "polo-box". The polo subfamily of protein kinases appears to play a critical role in cell proliferation and cell division. The polo-box domain of mammalian polo kinase, Plk, and the budding yeast functional homolog, Cdc5, are essential for their subcellular localization and functions. The two yeast mutants can be used to screen for inhibitors of polo-box function.
Inventors:
Kyung S. Lee (NCI) Sukgil Song (NCI)
Patent Status:
DHHS Reference No. E-100-2000/0 --
U.S. Provisional Application No. 60/206,588 filed 23 May 2000
PCT Application No. PCT/US01/16903 filed 23 May 2001, which published as WO 01/090401 on 23 Nov 2001
Portfolios: Cancer
Cancer -Diagnostics
For Additional Information Please Contact: Jennifer Wong
NIH Office of Technology Transfer
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Email: wongje@mail.nih.gov
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