Delayed Progression To AIDS By A Missense Allele Of The CCR2 Gene
Description of Invention:
A specific variant of chemokine receptor CCR2, which appears to be a co-receptor for HIV-1, has been identified. This variant, CCR2-64I, is associated with delayed progression to AIDS in individuals infected with HIV-1, and is the result of a conservative amino acid substitution within the first transmembrane receptor region of CCR2. CCR2-64I is independent of but additive with CCR5-d32, an allele of chemokine receptor CCR5 which is also associated with delayed progression to AIDS. Together, these two polymorphisms are present in nearly 40% of individuals in all ethnic groups; CCR2-64I alone occurs at an allele frequency of 10 - 29% in all ethnic groups. Polynucleotides and polypeptides are provided by the invention. Therapeutic approaches and pharmaceutical compositions are claimed, as are research uses, diagnostic uses, and screening methods.
For Additional Information Please Contact: Sally Hu PhD MBA
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5606
Email: hus@mail.nih.gov
Fax: (301) 402-0220
