Neutralizing Monoclonal Antibody To Human Alpha PDGF Receptors
Description of Invention:
These monoclonal antibodies specifically bind to an epitope on alpha PDGFR, inhibit PDGF binding with PDGF, antagonize PDGF, and does not bind beta PDGFR receptor. A hybridoma cell line producing such a monoclonal antibody, methods of in vivo imaging of a pathological condition, and methods of inhibiting the growth of a neoplasia expressing alpha PDGFR which use these monocloncal antibodies are also described. In vitro assays for detecting the presence of alpha PDGFR and for evaluating the binding affinity of a test compound are also described.
Inventors:
W LaRochelle (NCI) J Pierce (NCI) R Jensen (NCI) SA Aaronson (NCI)
Patent Status:
DHHS Reference No. E-040-1993/0 --
U.S. Patent 5,468,468 issued 21 Nov 1995
U.S. Patent 5,863,739 issued 26 Jan 1999
U.S. Patent 5,833,986 issued 10 Nov 1998
Portfolios: Internal Medicine Infectious Diseases Devices/Instrumentation Cancer
Cancer -Therapeutics-Immunoconjugates-Mab Devices/Instrumentation-Diagnostics-Imaging-Methods Cancer -Therapeutics Cancer -Research Materials Devices/Instrumentation-Diagnostics Infectious Diseases -Research Materials Internal Medicine-Other
For Additional Information Please Contact: Susan S. Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-4478
Email: ruckersu@mail.nih.gov
Fax: (301) 402-0220
