Assay for the Detection of a Variety of Tumors in Biological Specimens
Description of Invention:
The inventors have developed methods and reagents for the detection of bone sialoprotein (BSP) in biological samples. The technology relates to the disruption of a serum complex that masks the majority of BSP from established detection systems. Furthermore, there is evidence that there may be a more acidic form of BSP secreted not by normal bone, but only by tumors. Detection of BSP in serum may be a good marker of various bone diseases and a variety of cancers including breast, prostate, lung, and thyroid.
Inventors:
Larry W Fisher (NICHD) Neal S. Fedarko (NICHD) Marian F Young (NICHD)
Patent Status:
DHHS Reference No. E-173-1998/0 --
U.S. Patent No. 6,995,018 issued 07 Feb 2006
U.S. Patent Application No. 11/185,924 filed 19 Jul 2005
Portfolios: Cancer
Cancer -Diagnostics
For Additional Information Please Contact: Jennifer Wong
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301)435-4633
Email: wongje@mail.nih.gov
Fax: (301)402-0220
