Nucleotide, Deduced Amino Acid Sequence, Isolation And Purification Of Heat-Shock Chlamydial Proteins
Description of Invention:
This invention concerns the discovery of a novel gene that encodes the HSP60 protein from Chlamydia trachomatis, referred to as HypB in the application. This immunodominant protein is a major target for Chlamydia trachomatis vaccine development and diagnostics. This gene and protein, or fragments thereof, are useful in the development of both recombinant protein and DNA based vaccines. The recombinant protein or DNA sequence also have potential for the development of diagnostic tests for C. trachomatis. The three patent properties claim different aspects of the invention. U.S. Patent No. 5,071,962 claims monoclonal antibodies reactive against C. trachomatis HSP60 protein. U.S. Patent Application No. 07/841,323 claims the HSP60 protein and its use as a vaccine. U.S. Patent 6,423,835 claims DNA sequences, and protein fragments thereof, encoding HSP60. This DNA sequence would be useful in a DNA vaccine, alone or with the MOMP DNA sequences claimed in U.S. Patent 5,869,608 (DHHS Reference No. E-003-1989/0). No foreign patent rights exist.
Inventors:
RB Morrison (NIAID) HD Caldwell (NIAID)
Patent Status:
DHHS Reference No. E-196-1989/0 --
U.S. Patent 5,071,962 issued 10 Dec 1991
U.S. Patent Application No. 07/841,323 filed 25 Feb 1992
U.S. Patent 6,423,835 issued 23 Jul 2002
For Additional Information Please Contact: Susan Ano Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
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Phone: (301) 435-5515
Email: anos@mail.nih.gov
Fax: (301) 402-0220
