Nucleotide and Deduced Amino Acid Sequences of a New Tumor Gene, Int6
Description of Invention:
Murine retroviruses have been useful in the identification of mammalian genes involved in tumor development. Five loci have been previously identified as integration sites for one specific retrovirus, mouse mammary tumor virus (MMTV). This work describes a sixth site of integration for MMTV, the Int6 gene. The Int6 gene is highly conserved among vertebrate species, including humans. This invention embodies a series of reagents derived from the nucleic acid and amino acid sequences of the Int6 gene and the use of these reagents in diagnostic methods, immunotherapy, gene therapy, and as vaccines.
Inventors:
Robert Callahan (NCI) Antonio Marchetti (NCI) Fiamma Buttitta (NCI) Gilbert Smith (NCI)
Patent Status:
DHHS Reference No. E-265-1994/1-US-01 -- U.S. Patent 6,255,104 issued 03 Jul 2001, claiming priority to U.S. Patent Application No. 08/385,998 filed 09 Feb 1995, now abandoned (DHHS Reference No. E-265-1994/0-US-01) and PCT Application No. PCT/US96/01884 filed 09 Feb 1996, which published as WO 96/24672 on 15 Aug 1996 (DHHS Reference No. E-265-1994/0-PCT-02)
DHHS Reference No. E-265-1994/1-US-02 -- U.S. Patent 6,342,392 issued 29 Jan 2002
DHHS Reference No. E-265-1994/1-US-03 -- U.S. Patent 6,737,251 issued 18 May 2004
DHHS Reference No. E-265-1994/1-US-04 -- U.S. Patent Application No. 10/783,415 filed 19 Feb 2004
Licensing Status:
In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors.
Portfolios: Gene Based Therapies Cancer
Cancer -Diagnostics-In Vitro-DNA Based Cancer -Diagnostics-In Vitro-MAb Based Cancer -Diagnostics-In Vivo-MAb Cancer -Diagnostics-In Vivo-Conjugate Chemistry Cancer -Therapeutics-Gene Therapy-Vectors Cancer -Therapeutics-Gene Therapy-Genes Cancer -Diagnostics Cancer -Therapeutics Cancer -Research Materials Gene Based Therapies -Research Materials
For Additional Information Please Contact: Jasbir (Jesse) S. Kindra J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5559
Email: kindraj@mail.nih.gov
Fax: (301) 402-0220
