Description of Invention:
Stroke is the third leading cause of death and the leading cause of adult disability in developed countries. Despite the prevalence and burden of this disease, stroke precipitants and pathophysiological mechanisms in individual patients are often unknown. It is also difficult to accurately predict whether a stroke will lead to only minor neurological sequelae or more serious medical consequences. Although animal experiments in focally ischemic brain tissue have indicated that there are alterations in gene expression following a stroke, gene expression profiling has not yet been applied to clinical human stroke, primarily because brain tissue samples are inaccessible and rarely justified.
The present provisional patent application discloses methods of determining whether a subject had an ischemic stroke, methods of determining the prognosis of a subject who had an ischemic stroke, as well as methods of determining an appropriate treatment regimen for a subject who had an ischemic stroke.
Inventors:
Alison E. Baird (NINDS)
Patent Status:
DHHS Reference No. E-306-2003/0 --
U.S. Provisional Application No. 60/575,279 filed 27 May 2004
PCT Application No. PCT/US2005/18744 filed 27 May 2005, which published as WO 2005/116268 on 08 Dec 2005
For Additional Information Please Contact: Fatima Sayyid M.H.P.M.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-4521
Email: sayyidf@mail.nih.gov
Fax: (301) 402-0220
