Multi-Domain Amphipathic Helical Peptides and Methods of Their Use
Description of Invention:
Mutations in the ABCA1 transporter lead to diseases characterized by the accumulation of excess cellular cholesterol, low levels of HDL and an increased risk for cardiovascular disease. Currently, there are a wide variety of treatments for dyslipidemia, which include, but are not limited to, pharmacologic regimens (mostly statins), partial ileal bypass surgery, portacaval shunt, liver transplantation, and removal of atherogenic lipoproteins by one of several apheresis procedures.
The present invention relates to the composition of peptides or peptide analogs with multiple amphipathic alpha-helical domains that promote lipid efflux from cells. It further relates to methods for identifying non-cytotoxic peptides that promote lipid efflux from cells that are useful in the treatment and prevention of dyslipidemic and vascular disorders. Dyslipidemic and vascular disorders amenable to treatment with the isolated multi-domain peptides include, but are not limited to, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, HDL deficiency, apoA-I deficiency, coronary artery disease, atherosclerosis, thrombotic stroke, peripheral vascular disease, restenosis, acute coronary syndrome, and reperfusion myocardial injury.
Inventors:
Alan Remaley et al. (NHLBI)
Patent Status:
DHHS Reference No. E-114-2004/0 --
U.S. Provisional Application No. 60/619,392 filed 15 Oct 2004
PCT Application No. PCT/US2005/036933 filed 14 Oct 2005, which published as WO 2006/044596 on 27 Apr 2006
U.S. Patent Application No. 11/577,259 filed 13 Apr 2007
Licensing Status: In addition to licensing, the technology is available for further development through a collaborative research opportunity with the inventors. Details were provided in a CRADA/Licensing Opportunity notice published in the Federal Register on February 14, 2008 (73 FR 8702).
For Additional Information Please Contact: Fatima Sayyid M.H.P.M.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-4521
Email: sayyidf@mail.nih.gov
Fax: (301) 402-0220
