Autophagy and Antiviral Immunity |
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| Launch in standalone player | |
| Air date: | Wednesday, October 29, 2008, 4:15:00 PM |
| Category: | Immunology |
| Description: | Dr. Iwasaki’s research addresses the role of dendritic cells in the induction and maintenance of mucosal immunity, primarily to viral infections, such as HSV-2 and influenza virus. She has been instrumental in determining how T cell responses are induced in the vaginal tract to HSV-2, including the mechanisms of entry and dynamics of viral replication, the ability of DC subpopulations to process and present viral antigens both locally and within lymph nodes, and the role of DC and stromal cell activation by TLR receptors in inducing Th1 responses. She has also made fundamental discoveries on the basic biology of DC recognition and control of virus infections, including the first studies showing TLR9 recognition of viral DNA, and TLR7 activation by single-stranded viral RNA, as well as the importance of local plasmacytoid DCs in providing innate immune protection. Most recently, Dr. Iwasaki has demonstrated that the transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy is important pathway for the TLR7-dependent recognition of single-stranded RNA viruses by pDCs. Dr. Iwasaki is a dynamic scientist, who will most certainly deliver an entertaining and stimulating presentation. For more information, visit The Immunology Interest Group |
| Author: | Akiko Iwasaki, Ph.D., Department of Immunobiology, Yale University |
| Runtime: | 62 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 14732 |
| CIT Live ID: | 7078 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14732 |