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"Tell CCR" about newly accepted/in press papers prior to online and print publication. Please include a copy of the manuscript in your e-mail to tellccr@mail.nih.gov
Questions may be directed to Donna Kerrigan
Our News - 2007 Scientific Advances from CCR
CCR’s top scientific advances are selected each year by CCR senior staff. These may be promoted in one or more of the following ways:
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► development of an NCI press release
► inclusion in NCI's Budget Book
► inclusion in CCR’s Research Accomplishments
► publication in the NCI Cancer Bulletin
► publication in CCR connections
The advances selected for 2007 are shown below.
Basic Science
Advances in ABC Transporters – submission by Michael Gottesman:
“Silent” Mutations in a Multidrug-Resistance Gene Affect Cancer Diagnosis and Treatment
Advances in DNA Damage – submissions by Tom Misteli and Andre Nussenzweig:
Visualization of DNA Breaks in Living Cells
ATM Prevents the Persistence and Propagation of DNA Breaks
Advances in Chaperones – submissions by Sue Wickner and Leonard Neckers:
Asymmetric Deceleration of ClpB or Hsp104 ATPase Activity Unleashes Protein-Remodeling Activity
Identification of an Acetylation Site in the Middle Domain of Hsp90 that Regulates Its Function
Advances in Angiogenesis – submission by Triantafyllos Chavakis:
Regulation of the Vascular Endothelial Barrier by Junctional Adhesion Molecule-C
Advances in Chromosome Biology – submission by Carl Wu:
Discovery of Nonhistone Scm3 as a Crucial Component of the Core of Yeast Centromere
Translation/Clinical Science
Advances in Multiple Myeloma – submission by Louis Staudt and W. Michael Kuehl:
Frequent Engagement of the Classical and Alternative NF-kappaB Pathways by
Diverse Genetic Abnormalities Promotes Cell Survival in Multiple Myeloma
Advances in HIV/AIDS Therapy – submission by Hiroaki Mitsuya:
Development of Darunavir and Other Protease Inhibitors that Block the Dimerization Process of HIV-1 Protease
Advances Using Expression Profiling – submissions by Xin Wang and Stuart Yuspa:
New Biomarkers for Liver Cancer
Expression Profiling Reveals a Signature of High Cancer Risk in Benign Tumors
Advances in Ovarian Cancer – submission by Peter Choyke:
Targeted Imaging for Ovarian Carcinoma
Advances in Lung Cancer Treatment – submission by Phillip Dennis:
Identification of Rapamycin as an Effective Agent for the Prevention of Tobacco-Carcinogen Induced Lung Tumors
