Prussian Blue (Radiogardase®)
Indications and Usage
- This oral ion-exchange drug is indicated for decorporation of cesium and thallium and has been shown to be highly effective for Cs-137 contamination.
- Prussian blue is not FDA approved for rubidium.
- Prussian blue is not FDA approved for children under 2 years old (IND or EUA may be required). Pediatric prescribing information is included in package insert.
- It is benign, with the exception of occasional constipation.
- Stool turns blue.
- Provided as 0.5 gram of Prussian blue in gelatin capsules.
- Usual dose starts at 0.5 g capsule, 2 caps p.o. tid for up to 3 weeks or longer, as required.
Doses up to 10-12 g/day for significantly contaminated adults may be used.
- Prussian blue is available only by prescription.
- The CDC has included Prussian blue in the Strategic National Stockpile (SNS), a special collection of drugs and medical supplies that CDC keeps to treat people in an emergency.
- Other names for Prussian blue:
- Berlin blue
- ferric ferrocyanide
- ferric(III) hexacyanoferrate
- ferric hexacyanoferrate (II)
- Iron blue
- Radiogardase-Cs
- Fe4[Fe(Cn6)]3
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Reference Links
CDC resources
FDA resources
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References |
- Marcus, CS. Administration of decorporation drugs to treat internal radionuclide contamination: medical emergency response to radiologic incidents. RSO Magazine, 2004;9(5):9-15. (PDF - 34 KB)
- "Radiation Bioterrorism," Tochner ZA, Lehavi O, Glatstein E, Chapter 207 in Harrison's Principles of Internal Medicine, Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, eds. 16th Edition, pp 1294-1300, McGraw-Hill, 2005
- Management of Persons Accidentally Contaminated with Radionuclides, National Council on Radiation Protection and Measurements, NCRP Report No. 65, Bethesda, MD, 1980.
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