The Office of High Performance Computing and Communications (OHPCC) serves as the focal point for the NLM High Performance Computing and Communications (HPCC) activities. OHPCC coordinates NLM HPCC planning, research and development activities with Federal, industrial, academic, and commercial organizations while collaborating with Lister Hill Center research branches and NLM Divisions in the development, operation, evaluation and demonstration of HPCC research programs and projects. In addition, OHPCC plans, coordinates, and administers the interagency HPCC research and development program. Office staff serve as NLM liaison to scientific organizations at all levels of national, state and international government on planning and implementing research in High Performance Computing and Communications. The major research activities of the office center on the Visible Human Project, NLM Next Generation Internet Program, telemedicine, the HPCC Collaboratory, and the 3D informatics research program. The most current information about the Office of High Performance Computing and Communications can be found at http://lhncbc.nlm.nih.gov/ohpcc/