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Abstract

Title: N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease.
Author: Huang W, Zheng W, Urban DJ, Inglese J, Sidransky E, Austin CP, Thomas CJ
Journal: Bioorg Med Chem Lett 17(21):5783-5789
Year: 2007
Month: November

Abstract: A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related sugar hydrolases enzymes are described.