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Biometry Research Group

Curriculum Vitae for Pamela Margo Marcus, M.S., Ph.D.
Epidemiologist

US Mail Address
Biometry Research Group, DCP
National Cancer Institute
Executive Plaza North, Suite 3131
6130 Executive Boulevard, MSC 7354
Bethesda, MD 20892-7354
Shipping Address
Biometry Research Group, DCP
National Cancer Institute
6130 Executive Boulevard, Suite 3131
Rockville, MD 20852
Phone: 301-496-7468 • Fax: 301-402-0816
E-mail: pm145q@nih.gov


Date and Place of Birth:April 27, 1966; Brooklyn, New York
Citizenship:United States
Education:
June 1983Graduated from Sheepshead Bay High School
December 1986B.A. (Mathematics), Magna cum laude
City University of New York -- Baruch College
December 1990M.S. (Statistics)
University of Wisconsin-Madison
December 1993M.S. (Preventive Medicine -- Epidemiology)
University of Wisconsin-Madison
August 1997Ph.D. (Epidemiology)
University of North Carolina at Chapel Hill

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Brief Chronology of Employment:

1987-1988Actuarial Trainee
The Equitable Financial Companies
1988-1990Teaching Assistant
University of Wisconsin-Madison, Department of Statistics
1989-1990Research Assistant
University of Wisconsin-Madison, Comprehensive Cancer Center
1991-1994Associate Researcher
University of Wisconsin-Madison, Comprehensive Cancer Center
1995-1997Pre-doctoral Fellow
University of North Carolina at Chapel Hill, Department of Epidemiology
1996Teaching Assistant
University of North Carolina at Chapel Hill, Department of Epidemiology
1995-1997Research Assistant
University of North Carolina at Chapel Hill, Department of Epidemiology
1997Consultant
Glaxo Wellcome, Department of World Wide Epidemiology
1997-1999Cancer Prevention Post-Doctoral Fellow
Biometry Research Group, Division of Cancer Prevention
National Cancer Institute, National Institutes of Health
1999Adjunct Professor
Georgetown Public Policy Institute, Georgetown University
1999-DateEpidemiologist
Biometry Research Group, Division of Cancer Prevention
National Cancer Institute, National Institutes of Health

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Military Service: None

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Project Officer Responsibilities

  • Project Officer, Extended Lung Cancer Incidence Follow-Up for the Mayo Lung Project Participants. 2000-present
  • Assistant Project Officer, Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trail. 2001-present
  • Assistant Project Officer, Lung Screening Study component of the National Lung Screening Trial. 2001-present

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Societies

  • American Society of Preventive Oncology, Delta Omega Society, Theta Chapter

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Honors and Other Special Scientific Recognition

  • NCI Cancer Training Grant, 8/1994-8/1995
  • NCI Cancer Prevention and Control Pre-Doctoral Fellowship, 9/1995-7/1997
  • UNC School of Public Health Alumni Award, Department of Epidemiology, 1996
  • Poster Citation Award, American College of Epidemiology, Annual Scientific Sessions, 9/1998
  • AACR-GlaxoWellcome Oncology Clinical/Translational
    Research Scholar Award, 4/1999
  • On-The-Spot Award, DCP Newsletter, 12/1999
  • On-The-Spot Award, Lung Screening Study, 9/2000
  • Participant, Lung Cancer Progress Review Group, 5/2001
  • On-The-Spot Award, Clinical Breast Exam Project, 7/2001
  • On-The-Spot Award, National Lung Screening Trial, 7/2002

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Research Interests

  • Cancer Epidemiology and Screening
  • Clinical Trials
  • Case-Control Methodology for Assessment of Cancer Screening Modalities
  • Ethics of Prevention Research

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Bibliography

Newcomb PA, Norfleet RG, Storer BE, Surawicz TS, Marcus PM. Screening sigmoidoscopy and colorectal cancer mortality. Journal of the National Cancer Institute 1992;84:1572-1575.

Newcomb PA, Storer BE, Marcus PM. Cancer of the large bowel in women in relation to alcohol consumption: a case-control study in Wisconsin (United States). Cancer Causes and Control 1993;4:405-411.

Marcus PM, Newcomb PA, Storer BE. Early adulthood physical activity and colon cancer risk among Wisconsin women. Cancer Epidemiology, Biomarkers and Prevention 1994;3:641-644.

Trentham Diet A, Newcomb PA, Marcus PM, Storer BE: The association of body size and large bowel cancer risk in Wisconsin (United States) women. Cancer Causes and Control1995;6:30-36.

Reeves MJ, Newcomb PA, Remington PL, Marcus PM. Determinants of breast cancer detection among Wisconsin (United States) women, 1986-1990. Cancer Causes and Control 1995;6:103-111.

Newcomb PA, Klein R, Klein BEK, Haffner S, Mares-Perlman J, Cruickshanks KJ, Marcus PM. Association of dietary and lifestyle factors with sex hormones in postmenopausal women. Epidemiology 1995;6:318-321.

Marcus PM, Newcomb PA, Young T, Storer BE. The association of reproductive and menstrual characteristics and colon and rectal cancer risk in Wisconsin women. Annals of Epidemiology 1995;5:303-309.

Haffner SM, Newcomb PA, Mares-Perlman J, Marcus PM, Klein BEK, Klein R. Relationship of sex hormones to total and HDL cholesterol, and glycosylated hemoglobin in a population-based study of post-menopausal women. American Journal of Epidemiology 1995;142:925-934.

Newcomb PA, Storer BE, Marcus PM. Cigarette smoking in relation to risk of large bowel cancer in women. Cancer Research 1995;55:4906-4909.

Reeves MJ, Newcomb PA, Remington PL, Marcus PM, MacKenzie WR. Body mass and breast cancer: relationship between method of detection and stage of diagnosis. Cancer 1996;77:301-307.

Marcus PM, Savitz DA, Millikan RC, Morgenstern H. The association of total trihalomethanes in drinking water and breast cancer in North Carolina women. Epidemiology 1998;9:156-160.

Marcus PM, Newcomb PA. The association of calcium and vitamin D with colon and rectal cancer. International Journal of Epidemiology 1998;27:788-793.

Marcus PM, Prorok PC. Reanalysis of the Mayo Lung Project data: the impact of confounding and effect modification. Journal of Medical Screening 1999;6:47-49.

Marcus PM, Newman B, Millikan RC, Moorman PG, Baird DD, Sternfeld B, Qaqish B. Physical activity at age 12 and adult breast cancer risk (United States). Cancer Causes and Control 1999;10:293-302.

Marcus PM, Baird DD, Millikan RC, Moorman PC, Qaqish B, Newman B. Adolescent reproductive events and subsequent breast cancer risk. American Journal of Public Health 1999;89:1244-1248.

Marcus PM, Vineis P, Rothman N. NAT2 slow acetylation and bladder cancer risk: a meta-analysis of 22 studies. Pharmacogenetics 2000;10:115-122.

Marcus PM. Television as a venue for cancer education: the General Hospital experience. Journal of Cancer Education 2000;15:4.

Marcus PM, Newman B, Millikan RC, Moorman PG, Baird DD, Qaqish B. The association of adolescent cigarette smoking, alcoholic beverage consumption, environmental tobacco smoke, and ionizing radiation with subsequent breast cancer risk. Cancer Causes and Control 2000;11:271-278.

Marcus PM, Hayes RB, Vineis P, Garcia-Closas M, Caporaso NE, Autrup H, Branch RA, Brockmoller J, Ishizaki T, Karakaya AE, Ladero JM, Mommsen S, Okkels H, Romkes M, Roots I, Rothman N. Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction. Cancer Epidemiology, Biomarkers and Prevention 2000;9(5):461-467.

Marcus PM, Bergstralh E, Fagerstrom RM, Fontana R, Taylor W, Prorok PC. Lung cancer mortality in the Mayo Lung Project: The impact of extended follow-up. Journal of the National Cancer Institute 2000;92:1308-1316.

Marcus PM. Lung cancer screening: an update. Journal of Clinical Oncology. 2001;19S:83S-86S.

Marcus PM. Lung cancer screening, once again (letter). Chest 2002;122:3.

Engel LS, Taioli E, Pfeiffer R, Garcia-Closas M, Marcus PM, Lan Q, Boffetta P, Vineis P, Autrup H, Bell DA, Branch RA, Brockmöller J, Daly AK, Heckbert SR, Kalina I, Kang DH, Katoh T, Lafuente A, Lin HJ, Romkes M, Taylor JA, Rothman N. Pooled analysis and meta-analysis of GSTM1 and bladder cancer: A HuGE Mini-Review. American Journal of Epidemiology, 2002;156:95-109.

Marcus PM, Fagerstrom RM, Prorok PC, Gohagan JK, Kramer BS. Screening for lung cancer with helical CT (invited). Clinical Pulmonary Medicine 2002;9:323-329.

Church TR for the National Lung Screening Trial Executive Committee. Chest radiography as the comparison for spiral CT in the National Lung Screening Trial. Acad Radiol 2003;10:713-715.

Marcus PM. Conflicting evidence in lung cancer screening: randomized controlled trials versus case-control studies. Lung Cancer 2003;41:37-39.

Gohagan J, Marcus P, Fagerstrom R, Pinsky P, Kramer B, Prorok P. Baseline findings of a randomized feasibility trial of lung cancer screening with spiral CT scan vs chest radiograph. the Lung Screening Study of the National Cancer Institute. Chest 2004;126:114-112

Gohagan JK, Marcus PM , Fagerstrom RM, Pinsky PF, Kramer BS, Prorok PC, et al. Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest x-ray screening for lung cancer. Lung Cancer 2005;47(1):9-15.

Pinsky PF, Marcus PM , Kramer BS, Freedman M, Nath H, Kvale P, Reding D. Diagnostic procedures after a positive spiral computed tomography lung carcinoma screen. Cancer 2005;103:157-163.

Oken MM, Marcus PM, Hu P, Beck TM, Hocking W, Kvale PA, Cordes J, Riley TL, Winslow SD, Peace P, Levin DL, Prorok PC, Gohagan JK for the PLCO Project Team. Baseline chest radiograph for lung cancer detection in the randomized Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. J Natl Cancer Inst 2005; 97(24):1832-1839.

Marcus PM, Bergstralh EJ, Zweig MH, Harris A, Offord KP, Fontana RS. Extended lung cancer incidence follow-up in the Mayo Lung Project and overdiagnosis. Journal of the National Cancer Institute 2006;98(11):748-756.

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Submitted Manuscripts:

None

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Manuscripts in Preparation:

Marcus PM, Rothman N, Caporaso NE. CYP2D6 (debrisoquine metabolism) and lung cancer histology.

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Published Abstracts:

Newcomb PA, Storer BE, Marcus PM. Sigmoidoscopy and the incidence of large bowel cancer in women. Cancer Epidemiology Biomarkers and Prevention 1992;1(3):250.

Newcomb PA, Storer BE, Marcus PM. Cancer of the large bowel in relation to use of hormone replacement therapy. American Journal of Epidemiology 1992;136:958.

Newcomb PA, Storer BE, Marcus PM. Cigarettes smoking, menopausal status, and large bowel cancer incidence in women. Cancer Epidemiology, Biomarkers and Prevention 1993;2:180.

Newcomb PA, Storer BE, Marcus PM. Risk factors for carcinoma in situ of the breast. Cancer Epidemiology Biomarkers and Prevention 1994;3:189.

Marcus PM, Newcomb PA, Storer BE. The association of calcium, vitamin D and dairy products and colon and rectal cancer in Wisconsin women. American Journal of Epidemiology 1995;141:S70.

Marcus PM, Newman B, Millikan RC, Moorman PG, Baird DD, Qaqish B, Sternfeld B. The association of adolescent body mass and physical activity with subsequent breast cancer risk. American Journal of Epidemiology 1997;145:S23.

Marcus PM, Moorman PG, Millikan RC, Baird DD, Qaqish B, Newman B. Adolescent reproductive events and subsequent breast cancer risk. Breast Cancer Research and Treatment 1997;46:82.

Marcus PM, Newman B, Millikan RC, Moorman PG, Baird DD, Qaqish B. The association of adolescent cigarette smoking, alcoholic beverage consumption, environmental tobacco smoke (ETS), and ionizing radiation with subsequent breast cancer risk. Annals of Epidemiology 1998;8:444.

Marcus PM, Hayes RB, Vineis P, Garcia-Closas M, Caporaso NE, Rothman N. NAT2 slow acetylation and cigarette smoking; a meta-analysis of their interactive effect on bladder cancer risk among 1,986 cases. Proceedings of the American Association for Cancer Research 1999;40: abstract #1407.

Marcus PM, Newman B, Millikan RC, Baird DD, Moorman PG, Qaqish B. Breast cancer epidemiology: the case for adolescent exposures. American Journal of Epidemiology 1999;149:S27.

Marcus PM, Vineis P, Rothman N. NAT2 slow acetylation and bladder cancer risk: a meta-analysis of 24 case-control studies. American Journal of Epidemiology 1999;149:S48.

Marcus PM, Bergstralh EJ, Fagerstrom RM, Williams DE, Fontana R, Taylor WF, Prorok PC. Lung cancer mortality in the Mayo Lung Project: the impact of extended follow-up. Cancer Epidemiology, Biomarkers &Prevention 2000;9:233.

Marcus PM, Rothman N, Caporaso N. CYP2D6 (debrisoquine metabolism) and lung cancer histology. American Journal of Epidemiology 2000;151:S25.

Marcus PM, Fagerstrom R, Church T, Prorok P,Gohagan J. Choosing a control-arm intervention in cancer screening trials when standard of care is unclear. Controlled Clinical Trials 2003;24:224S.

Fagerstrom RM, Marcus PM, Prorok PC, Kramer BS, Greenwald P, Gohagan JK. Issues in the design, operations, and analysis of multi-disease screening trials: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial Experience. Controlled Clinical Trials 2003;24:57S.

Kvale PA, Gohagan J, Marcus P, Fagerstrom R, Pinsky P, Kramer B, Prorok P. The lung screening study: the National Cancer Institute's randomized feasibility study of spiral CT versus chest x-ray in lung cancer screening. Chest 2003;124:118S-118S.

Marcus PM, Bergstralh EJ, Zweig MH, Harris A, Offord KP, Fontana RS. Evidence of overdiagnosis in lung cancer screening. Cancer Epidemiology, Biomarkers and Prevention 2004;13:332.

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Presentations:

Fiore MC, Newcomb PA, Ritter LD, Marcus PM. Smoking characteristics and the efficacy of nicotine gum. Presented to the 15th Annual Meeting of the American Society for Preventive Oncology, Seattle, WA, April 1991.

Maltzman TE, Marcus PM, Newcomb PA. A comparison of breast cancer risk factors in premenopausal black and white women. Presented to the 15th Annual Meeting of the American Society for Preventive Oncology, Seattle, WA, April 1991.

Newcomb PA, Storer BE, Marcus PM. Screening sigmoidoscopy and incidence of large bowel cancer in women. Presented to the 16th Annual Meeting of the American Society for Preventive Oncology, Bethesda, MD, March 1992.

Newcomb PA, Marcus PM. Cancer of the large bowel in relation to use of hormone replacement therapy. Presented to the 25th Annual Meeting of the Society for Epidemiologists, Minneapolis, MN, June 1992.

Newcomb PA, Marcus PM, Storer BE. Cigarette smoking, menopausal status and large bowel cancer incidence in women. Presented to the 17th Annual Meeting of the American Society for Preventive Oncology, Bethesda, MD, March 1992.

Marcus PM, Newcomb PA. Is vigorous physical activity in young adulthood protective against colon cancer in women? Presented to the 18th Annual Meeting of the American Society for Preventive Oncology, Tucson, AZ March 1993.

Marcus PM, Newcomb PA. Parity, age at first full term pregnancy and colorectal cancer in Wisconsin women. Presented to the 19th Annual Meeting of the American society for Preventive Oncology, Bethesda, MD, March 1994.

Newcomb PA, Storer BE, Marcus PM. Risk factors for carcinoma in situ of the breast. Presented to the 19th Annual Meeting of the American Society for Preventive Oncology, Bethesda, MD, March 1994.

Trentham Dietz A, Newcomb PA, Marcus PM. Weight and risk of large bowel cancer in women. Presented to the 19th Annual Meeting of the American Society for Preventive Oncology, Bethesda, MD, March 1994.

Reeves MJ, Newcomb PA, Remington PL, Marcus PM. Determinants of breast cancer detection in Wisconsin women. Presented to the 19th Annual Meeting of the American Society for Preventive Oncology, Bethesda, MD, March 1994.

Marcus PM, Newcomb PA, Storer BE. The association of calcium, vitamin D and dairy products and colon and rectal cancer in Wisconsin women. Presented to the 28th Annual Meeting of the Society for Epidemiologic Research, Snowbird, Utah, June 1995.

Marcus PM, Longnecker MP, Storer BE, Greenberg ER, Willett WC, Newcomb PA. Female infertility and breast cancer risk. Presented to the 21st Annual Meeting of the American Society for Preventive Oncology. Bethesda, MD, March 1996.

Marcus PM, Savitz DA, Millikan RC, Morgenstern H. Female breast cancer and trihalomethane levels in drinking water in North Carolina. Presented to the 5th Annual North Carolina Cancer Symposium. Durham, NC, February 1997.

Marcus PM, Rockhill B, Furberg H, Millikan RC, Moorman PG, Newman B. Reproductive risk factors for breast cancer among African-American women in the Carolina Breast Cancer Study. Presented to the 19th Annual Minority Health Conference. Chapel Hill, NC, February 1997.

Marcus PM, Newman B, Millikan RC, Moorman PG, Baird DD, Qaqish B, Sternfeld B. The association of adolescent body mass and physical activity with subsequent breast cancer risk. Presented to the 30th Annual Meeting of the Society for Epidemiologic Research. Edmonton, Alberta, Canada, June, 1997.

Marcus PM, Newman B, Moorman PG, Millikan RC, Qaqish B, Sternfeld B. The association of adolescent physical activity with breast cancer risk. Presented to the National Action Plan on Breast Cancer Workshop on Physical Activity and Breast Cancer. Albuquerque, NM, November, 1997.

Marcus PM, Moorman PG, Millikan RC, Baird DD, Qaqish B, Newman B. Adolescent reproductive events and subsequent breast cancer risk. Presented to the 20th Annual San Antonio Breast Cancer Symposium. San Antonio, TX, December, 1997.

Marcus PM. Telephone calls to the Cancer Information Service (CIS) in response to a daytime television storyline on breast cancer. Presented at the 22nd Annual Meeting of American Society of Preventive Oncology. Bethesda, MD, March, 1998.

Marcus PM, Newman B, Millikan RC, Moorman PG, Baird DD, Qaqish B. The association of adolescent cigarette smoking, alcoholic beverage consumption, environmental tobacco smoke (ETS), and ionizing radiation with subsequent breast cancer risk. Presented to the 1998 Annual Meetings of the American College of Epidemiology. San Francisco, CA, September, 1998.

Marcus PM, Prorok PC. Reanalysis of the Mayo Lung Project data: the impact of confounding and effect modification. Presented to the 1998 National Institutes of Health Research Festival. Bethesda, MD, October, 1998.

Garcia-Closas M, Marcus P, Lubin J, Rothman N. Gene-environment interaction in population-based studies: the example of NAT2, smoking and bladder cancer. Presented at the Schilling Research Conference on the Environment and Cancer (American Cancer Society). Santa Cruz, CA, March, 1999.

Marcus PM, Hayes RB, Vineis P, Garcia-Closas M, Caparaso NE, Rothman N. NAT2 slow acetylation study and cigarette smoking: a meta-analysis of their interactive effect on bladder cancer risk among 1,986 cases. Presented to the 90th Annual Meeting of the American Association for Cancer Research. Philadelphia, PA, April, 1999.

Rothman N, Caporaso NE, Wacholder S, Garcia-Closas M, Lubin JH, Marcus PM, Hoover RN, Fraumeni JR JF. Evaluation of interactions between environmental exposures and common genetic polymorphisms: a population-based epidemiologic perspective. Presented to the 90th Annual Meeting of the American Association for Cancer Research. Philadelphia, PA, April, 1999.

Marcus PM, Newman B, Millikan RC, Baird DD, Moorman PG, Qaqish B. Breast cancer epidemiology: the case for adolescent exposures. Presented to the 32nd Annual Meeting of the Society for Epidemiologic Research. Baltimore, MD, June, 1999.

Marcus PM, Vineis P, Rothman N. NAT2 slow acetylation and bladder cancer risk: a meta-analysis of 24 case-control studies. Presented to the 32nd Annual Meeting of the Society for Epidemiologic Research. Baltimore, MD, June, 1999.

Marcus PM, Bergstralh EJ, Fagerstrom RM, Williams DE, Fontana R, Taylor WF, Prorok PC. Lung cancer mortality in the Mayo Lung Project: the impact of extended follow-up. Presented to the 24th Annual Meeting of the American Society of Preventive Oncology. Bethesda, MD, March 2000.

Marcus PM, Rothman N, Caporaso N. CYP2D6 (debrisoquine metabolism) and lung cancer histology. Presented to the 33rd Annual Meeting of the Society for Epidemiologic Research. Seattle, WA, June 2000.

Marcus PM. Lung cancer screening, circa 2000. Presented at the 25th Annual Meeting of the American Society of Preventive Oncology. New York, NY, March 2001. (Invited)

Engel LS, Taoli E, Boffetta P, Lan Q, Veneis P, Marcus PM, Rothman N. Meta-analysis of the GSTM1 null genotype and risk of bladder cancer. Presented to the 92nd Annual Meeting of the American Association for Cancer Research. New Orleans, LA, April 2001.

Marcus PM. Lung cancer screening: an update. Presented to the 37th Annual Meeting of the American Society for Clinical Oncology. San Francisco, CA, May 2001. (Invited)

Marcus PM. Screening for lung cancer: is it ready for prime time? Presented to the Sixth Annual National VA Oncology Symposium. Alexandria, VA, January 2002. (Invited)

Marcus PM. Lung cancer screening: an update. Presented to the Annual Sessions of the American College of Physicians-American Society of Internal Medicine. Philadelphia, PA, March 2002. (Invited)

Marcus PM. How biased are case-control studies of screening? Presented to the Annual Sessions of the European Breast Cancer Network, International Breast Screening Network. Stockholm, Sweden, June 2003. (Invited)

Marcus PM, Fagerstrom RM, Church T, Prorok PC, Gohagan JK. Choosing a control-arm intervention in cancer screening trials when standard of care is unclear. Presented at the Third Joint Meeting of the International Society for Clinical Biostatistics and the Society for Clinical Trials. London, England, July 2003.

Fagerstrom RM, Marcus PM, Prorok PC, Kramer BS, Greenwald P, Gohagan JK. Issues in the design, operations, and analysis of multi-disease screening trials: The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial experience. Presented to the Third Joint Meeting of the International Society for Clinical Biostatistics and the Society for Clinical Trials. London, England, July 2003.

Marcus PM, Bergstralh EJ, Zweig MH, Harris A, Offord KP, Fontana RS. Evidence of over diagnosis in lung cancer screening .Presented to the 28th Annual Meeting of the American Society of Preventive Oncology. Bethesda, MD, March 2004.

Marcus PM. Epidemiology, biostatistics, and you:it's all about the data. Presented to the Annual SCORE Workshop. Bethesda, MD, March 2004. (Invited)

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Book Chapters:

Marcus PM, Travis WD. Lung. In Franco EL, Rohan TE (eds). Cancer Precursors: Epidemiology, Detection, and Prevention. New York:Springer-Verlag, 2002;201-219

Gohagan JK, Marcus PM, Fagerstrom RM, Black WC, Kramer BS, Pinsky PF, Prorok PC. Screening for lung cancer. In Gibson PG, Abramson M, Wood-Baker R, Volmink J, Hensley M, Costabel U (eds). Evidence-Based Respiratory Medicine. Malden, MA:Blackwell Publishing, 2005;81-87.

Gohagan JK, Marcus PM, Fagerstrom RM, Black WC, Kramer BS, Pinsky PF, Prorok PC. Screening for lung cancer. In Williams C (ed). Evidence-Based Oncology. London:BMJ Books, 2003;164-171.

Marcus PM. In: Jeffries LP (ed). Lung Cancer Screening. Hauppauge, NY:Nova Science Publishers, 2006;51-80

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This page was last updated June 18, 2007