Sodium Bicarbonate
Indications and Usage
- Used to alkalinize the urine after uranium intake, which protects the kidneys from uranium deposition.
- 2 ampules of sodium bicarbonate (44.3 mEq each) in 1000 cc D5W @125 cc/hr.
- Therapy can be monitored and guided by collecting 24-hour urine and fecal specimens and analyzing for uranium content as well as for chemical toxicity (e.g., proteins, microglobulin, casts). Serum renal function tests should also be monitored.
FDA Product Safety Info
- Not FDA approved for this indication/off-label use
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Reference Links
There is minimal actual clinical experience in the treatment of uranium-exposed
patients with NaHCO3, but NCRP
65 and some medical experts consider it safe
and reasonable.
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References |
- Marcus, CS. Administration of decorporation drugs to treat internal radionuclide contamination: medical emergency response to radiologic incidents. RSO Magazine, 2004;9(5):9-15. (PDF - 34 KB)
- "Radiation Bioterrorism," Tochner ZA, Lehavi O, Glatstein E, Chapter 207 in Harrison's Principles of Internal Medicine, Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, eds. 16th Edition, pp 1294-1300, McGraw-Hill, 2005
- Management of Persons Accidentally Contaminated with Radionuclides, National Council on Radiation Protection and Measurements, NCRP Report No. 65, Bethesda, MD, 1980.
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