PSA Progression Rates Among Men with Recurrent Prostate Cancer
Date Submitted: January 4, 2002
Objectives:
- to determine the PSA progression rates among men who have recurrent prostate cancer following radical surgery, radiation therapy, brachytherapy or watchful waiting;
- to describe PSA progression rates as exponential functions;
- to determine the distribution of PSA progression rates;
- to correlate PSA progression rates with initial Gleason score, initial PSA, treatment and other demographic factors such as age and race.
Rationale:
Preliminary analysis of data concerning clinical outcomes of a large retrospective cohort of men diagnosed with prostate cancer in Connecticut between 1990 and 1992 suggests
that PSA progression rates can be described as an exponential function. Specifically, when doubling times are plotted on a logarithmic scale, the rates appear to be almost linear.
We hypothesize that the PSA progression rates have a relatively wide, but normal distribution and that the rate constants are correlated with the initial Gleason score. Furthermore,
we hypothesize that the PSA progression rate can serve as an accurate predictor of the need for anti-androgen therapy.
Data:
PSA values for those men who show evidence of disease progression following primary diagnosis and treatment. In addition, we will require data concerning initial Gleason score, PSA,
and basic demographics.
Methods:
Currently being developed by Dr. Hanley.
Dissemination:
Results will be summarized in a manuscript that will be submitted to an appropriate peer-reviewed journal.
Target Schedule:
Analyses to begin October, 2002
First draft completed December, 2002
Draft submitted February, 2003
Collaborators:
Peter Albertsen (lead), James Hanley
Contact Information:
Peter Albertsen, MD
Division of Urology
University of Connecticut Health Center
Farmington, CT 06030-3955
Phone: 860-679-3676
Fax: 860-679-1318
E-mail: Albertsen@nso.uchc.edu
<< Previous Project | Next Project >>
|
