Section on Developmental Genomics

Head: Wai-Yee Chan

We study the regulation of gene expression and function during development in health and disease by applying functional genomic and systems biology approaches to spermatogenesis, a well-characterized developmental process. Availability of male germ cells at specific developmental stages permits the characterization of stage-specific gene expression and biological pathways.

Studies in cell models revealed a novel role of hCG in neuronal development. Applying genomic approaches to clinical medicine, we used the technologies that we developed to investigate selected clinical conditions, particularly those with abnormal cell growth. Our studies on testicular tumor and the role of mitochondria in tumorigenesis have resulted in observations that may eventually prove invaluable in the diagnosis, prognosis, and treatment of these conditions.

Resources

• Employee Listing
• E-Mail the Lab: chanwa@mail.nih.gov
• SDG Home Page