Section on Clinical Genomics

Head: Owen M. Rennert

The Section on Clinical Genomics, led by Owen Rennert, applies information gained from biochemical and genomic studies to clinical investigations. Using the database generated by the Section on Developmental Genomics, members of the Section on Clinical Genomics cloned several genes, including the novel gene mArd2, and demonstrated testis specificity and elevated expression in pachytene spermatocytes. Subsequent studies showed that Ard2 has acetyltransferase activity and may be responsible for compensating for the loss of X-linked transacetylation activity during meiosis and post-meiotic differentiation in germ cells. The section also applied genomic approaches to the study of human diseases, designing two hybridization-based high-throughput methods for screening susceptible risk factors for thrombophilia and age-related macular degeneration, providing a more accurate tool for risk calculation and disease prediction for these two complex disorders. 

Resources

• Employee Listing
• E-Mail the Lab: rennerto@mail.nih.gov
• SCG Home Page