Unit on Developmental Neurogenetics

Head: Sohyun Ahn

Using the genetic fate mapping approach, we have shown that adult neural stem cells (NSCs) in mouse forebrain respond to Sonic hedgehog (Shh) signaling. The Shh-responsive NSCs self-renew and generate several cell types of the nervous system. Using conditional ablation of major effectors of the Shh signaling pathway, we are currently investigating the mechanism by which Shh signaling maintains and regulates proliferation and differentiation of quiescent NSCs. Moreover, we are pursuing identification of novel downstream target genes of Shh signaling in NSCs in order to understand stem cell behavior. Finally, we have undertaken novel genetic approaches to study the biological role of newly generated neurons in the adult mouse forebrain by analyzing the neural circuits they form. The studies will provide the foundation needed for stem cell biology to develop therapeutic methods for treating various neurodegenerative diseases.

Resources

• Employee Listing
• E-Mail the Lab: ahnsohyun@mail.nih.gov
• UDN Home Page