Cellular and Molecular Neurophysiology

Head: Mark Lee Mayer

Neurotransmitter receptors and voltage-dependent ion channels regulate information processing in the central nervous system via complex, integrative interactions. In this group we study receptors and ion channels and the cellular processes they control using patch clamp, imaging, molecular biological, biochemical, structural and neuroanatomical techniques applied to a broad variety of preparations, including transgenic mice, brain slices, cell cultures, in vitro expression systems including Xenopus oocytes and transiently transfected 293 cells, and proteins overexpressed in bacteria. These approaches tell us how ion channels work, how their development and expression are regulated, and how they interact with the cellular biology of neurons and glia.

Resources

• Employee Listing
• E-Mail the Lab: mlm@helix.nih.gov

Units and Sections

• Section on Neurophysiology and Biophysics
  Head: Mark Lee Mayer