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Sponsors and Collaborators: |
National Institute on Aging (NIA) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Center for Research Resources (NCRR) |
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Information provided by: | National Institute on Aging (NIA) |
ClinicalTrials.gov Identifier: | NCT00099697 |
The purpose of this study is to determine whether DHEA replacement therapy decreases abdominal fat and improves insulin sensitivity.
Condition | Intervention |
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Aging Obesity Insulin Resistance |
Drug: DHEA |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double-Blind, Placebo Control |
Official Title: | Biologic Effects of DHEA in Humans |
Estimated Enrollment: | 56 |
Study Start Date: | June 2001 |
Estimated Study Completion Date: | February 2004 |
Studies on rats and mice have shown that the adrenal hormone dehydroepiandrosterone (DHEA) reduces abdominal visceral fat and protects against insulin resistance. This study was done to learn if DHEA replacement therapy decreases abdominal obesity and improves insulin action in humans.
Participants were randomly assigned to receive 50 mg per day of DHEA or a placebo at bedtime for 6 months. Participants underwent magnetic resonance imaging (MRI) and oral glucose tolerance tests at the beginning and conclusion of the study. Other tests included measurements of hormones and lipids.
Ages Eligible for Study: | 65 Years to 78 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, Missouri | |
Washington University School of Medicine | |
St. Louis, Missouri, United States, 63110 |
Principal Investigator: | John O. Holloszy, MD | Washington University School of Medicine |
Principal Investigator: | Dennis T. Villareal, MD | Washington University School of Medicine |
Study ID Numbers: | AG0013, 5P60AG013629, 5R01AG020076, 5K23RR016191, 3P30DK056341, 5P60DK020579, 2M01RR000036 |
Study First Received: | December 17, 2004 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00099697 |
Health Authority: | United States: Federal Government |
abdominal fat dehydroepiandrosterone Insulin sensitivity |
Obesity Metabolic Diseases Dehydroepiandrosterone Overweight Insulin Body Weight Hyperinsulinism |
Signs and Symptoms Nutrition Disorders Overnutrition Insulin Resistance Glucose Metabolism Disorders Metabolic disorder |
Immunologic Factors Physiological Effects of Drugs Adjuvants, Immunologic Pharmacologic Actions |