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| Sponsors and Collaborators: |
National Cancer Institute (NCI) American College of Radiology Imaging Network |
|---|---|
| Information provided by: | National Cancer Institute (NCI) |
| ClinicalTrials.gov Identifier: | NCT00047385 |
Purpose
RATIONALE: Screening tests may help doctors detect cancer cells early and plan more effective treatment for lung cancer. It is not yet known whether helical CT scan is more effective than chest x-ray in reducing death from lung cancer.
PURPOSE: Randomized clinical trial to compare the effectiveness of helical CT scan with that of chest x-ray in screening individuals who are at high risk for developing lung cancer.
| Condition | Intervention |
|---|---|
|
Lung Cancer |
Procedure: bronchoscopic and lung imaging studies Procedure: comparison of screening methods |
| Study Type: | Interventional |
| Study Design: | Screening, Randomized, Active Control |
| Official Title: | National Lung Screening Trial |
| Study Start Date: | September 2002 |
OBJECTIVES:
OUTLINE: This is a randomized, multicenter study. Participants are randomized to 1 of 2 screening arms.
Participants will then be contacted annually by mail or telephone for several years.
The National Lung Screening Trial (NLST) represents the union of two NCI-sponsored activities, the NCI Lung Screening Study I and the American College of Radiology Imaging Network (ACRIN). For more information, please access the ACRIN trial on Cancer.gov. The protocol ID is ACRIN-6654.
PROJECTED ACCRUAL: A total of 50,000 participants will be accrued for this study within 2 years.
Eligibility| Ages Eligible for Study: | 55 Years to 74 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
Age
Performance status
Life expectancy
Hematopoietic
Hepatic
Renal
PRIOR CONCURRENT THERAPY:
Biologic therapy
Chemotherapy
Endocrine therapy
Radiotherapy
Surgery
Contacts and Locations
Show 37 Study Locations| Study Chair: | Christine D. Berg, MD | NCI - Early Detection Research Group |
| Principal Investigator: | Denise R. Aberle, MD | Jonsson Comprehensive Cancer Center |
More Information
| Study ID Numbers: | CDR0000257938, NCI-NLST, ACRIN-NCI-NLST |
| Study First Received: | October 3, 2002 |
| Last Updated: | July 23, 2008 |
| ClinicalTrials.gov Identifier: | NCT00047385 |
| Health Authority: | United States: Federal Government |
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small cell lung cancer non-small cell lung cancer |
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Thoracic Neoplasms Carcinoma, Small Cell Non-small cell lung cancer Respiratory Tract Diseases |
Lung Neoplasms Lung Diseases Carcinoma, Non-Small-Cell Lung |
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Respiratory Tract Neoplasms Neoplasms Neoplasms by Site |
