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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00000554 |
To evaluate innovative diagnostic methods that will improve the diagnostic reliability of cardiovascular testing in evaluation of ischemic heart disease in women. Innovative approaches proposed include physiologic or functional measurements such as impaired metabolism, perfusion, or endothelial function as well as assessment of epicardial coronary arteries by angiography. Other objectives include developing safe, accurate, and cost effective diagnostic approaches for evaluating women with suspected ischemic heart disease, and determining the frequency of myocardial ischemia in the absence of significant epicardial coronary stenosis, as well as the frequency of non-ischemic or non-cardiac chest pain. A key aspect of the WISE study is to determine whether evidence of myocardial ischemia occurs in the absence of obstructive coronary disease.
Condition | Intervention | Phase |
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Angina Pectoris Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia |
Procedure: Angiography, MRI, Dobutamine-Stress Echocardiography, PET, Procedure: Myocardial Contrast Echo, Coronary Flow and Vasomotor Testing |
Phase III |
Study Type: | Interventional |
Study Design: | Diagnostic |
Study Start Date: | May 2001 |
Study Completion Date: | April 2007 |
Primary Completion Date: | April 2007 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 15 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Women over the age of 18 who have suspected ischemic heart disease.
Investigator: | Sheryl Kelsey | University of Pittsburgh |
Investigator: | Carl Pepine | University of Florida |
Investigator: | Steven Reis | University of Pittsburgh |
Investigator: | Steven Reis | University of Pittsburgh |
Study ID Numbers: | 98 |
Study First Received: | October 27, 1999 |
Last Updated: | January 15, 2008 |
ClinicalTrials.gov Identifier: | NCT00000554 |
Health Authority: | United States: Federal Government |
Arterial Occlusive Diseases Heart Diseases Myocardial Ischemia Angina Pectoris Vascular Diseases Pain Ischemia |
Arteriosclerosis Dobutamine Chest Pain Coronary Disease Signs and Symptoms Coronary Artery Disease |
Pathologic Processes Cardiovascular Diseases |