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Volume III, Issue 3 September 2002  
 
Four More Years for the CRN!
CRN Renewal Application rated "Excellent"

The fate of the CRN has been decided by a study section panel that was convened by NCI in late June. We are excited to report that we will be funded for four more years. Many changes are on the horizon, and plans are already under way for implementation of these changes.

Overall, our application received a qualitative rating of "Excellent," and a priority score of 171, which is in the fundable range. The critiques were generally very thoughtful, and give us clear messages about what we need to do to bolster the CRN as a research program during the next cycle. The next step will be to respond to the major criticisms and suggestions that emerged from the study section review. We will submit a so-called "best and final offer" to NCI, along with revised budgets, in early November. The "take-home messages" from the Summary Statement are described below for our Infrastructure. Future issues of this newsletter will provide comprehensive features on each of the new projects. CRN Infrastracture

We were commended for achieving a successful collaborative model, and for the great potential generated by the size and diversity of this network. Reviewers took note of the several new projects that have taken root in the CRN, and commended us on assembling a well-credentialed multidisciplinary team. Several times throughout the infrastructure critique, the evidence of our synergy and integration was highlighted. Most importantly, the CRN was recognized as having significant potential to advance scientific knowledge and research on cancer care.

Glowing compliments aside, we have a great deal of work ahead of us in the next four year cycle. Our two major shortcomings were lack of data standardization, and insufficient connectivity between the Infrastructure and the Research Projects. We did emphasize these facts in the application, (perhaps giving them too much emphasis). Nevertheless, since we recognize these weaknesses and the reviewers recognize them as

well, it is definitely time to start working on ways to overcome them. Data Standardization We need to consider a constellation of factors as we undertake data standardization initiatives, including:
  • what "place" a standardized data warehouse will occupy in the CRN (i.e., its purpose)
  • ambitious nature of constructing virtual data warehouses
  • data compatibility
  • clarity about who leads, develops, and populates our virtual data warehouses
  • reaching agreement about where data reside and who can access them
  • priority order for standardizing different types of data
  • how our experiences on the current projects can inform this process
  • privacy issues (HIPAA, state laws, HMO policies, human subjects, etc.)
Better Connectivity between Projects and Infrastructure

Notably, one reviewer states, "Not one of the proposed projects mentions any support to be received from the Infrastructure core." There are other similar statements along these lines, although the whole of our collaboration is still viewed as greater than the sum of the parts. How do we go about increasing connectivity? For starters, we are launching the Project Leaders' Forum, and establishing a Scientific and Data Resources Core. Other strategies will be debated at the October meeting of the Steering Committee and Academic Liaison Committee at NCI.

Once again, our thanks go out to all of you for helping us achieve the aims of our first cycle. We are enthusiastic about applying what we've learned so far, and improving on the synergy and capacity of the CRN.

- Sarah Greene, GHC

CRN News & Milestones

An administrative supplement on HRT initiation and cessation following results from the Women's Health Initiative was submitted to NCI and has been approved for funding. The Early Screening study's paper on the effectiveness of masking medical record abstractors has been accepted for publication in the American Journal of Epidemiolgy. Four CRN sites participated in a Center of Excellence in Cancer Communications Research grant, submitted on August 15. An R01 on the etiology of pancreatic cancer is slated for an October 1 submission.

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