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Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institute of Neurological Disorders and Stroke (NINDS) |
ClinicalTrials.gov Identifier: | NCT00004728 |
The purpose of this study is to determine whether aspirin or warfarin is more effective in preventing stroke in patients with intracranial stenosis.
Condition | Intervention | Phase |
---|---|---|
Stroke Cerebral Infarction Atherosclerosis Constriction, Pathologic |
Drug: Warfarin Drug: Aspirin |
Phase III |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double-Blind |
Official Title: | Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) Study |
Estimated Study Completion Date: | July 2003 |
Prevention of stroke in patients with narrowing of one of the arteries in the brain typically consists of using medications to prevent blood clots from forming. Currently, the best medication to use in this situation is unknown. The purpose of this study is to compare the effectiveness of two different medications, warfarin or aspirin, for the prevention of stroke due to narrowing of one of the large arteries in the brain. Patients must have experienced a recent transient ischemic attack (TIA) or mild stroke. Stroke of this type is thought to occur more often in minorities.
Ages Eligible for Study: | 40 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | R01NS36643 |
Study First Received: | February 25, 2000 |
Last Updated: | June 5, 2006 |
ClinicalTrials.gov Identifier: | NCT00004728 |
Health Authority: | United States: Federal Government |
stroke cerebral infarction warfarin coumadin aspirin ASA acetysalicylic acid atherosclerosis |
stenosis intracranial artery arteries transient ischemic attack TIA minorities |
Pathological Conditions, Anatomical Atherosclerosis Arterial Occlusive Diseases Ischemic Attack, Transient Cerebral Infarction Stroke Vascular Diseases Central Nervous System Diseases Constriction, Pathologic Warfarin |
Ischemia Arteriosclerosis Brain Diseases Cerebrovascular Disorders Necrosis Aspirin Brain Ischemia Brain Infarction Infarction |
Anti-Inflammatory Agents Anticoagulants Molecular Mechanisms of Pharmacological Action Cyclooxygenase Inhibitors Hematologic Agents Nervous System Diseases Physiological Effects of Drugs Enzyme Inhibitors Fibrinolytic Agents Cardiovascular Agents Pharmacologic Actions Fibrin Modulating Agents |
Pathologic Processes Analgesics, Non-Narcotic Sensory System Agents Therapeutic Uses Platelet Aggregation Inhibitors Cardiovascular Diseases Anti-Inflammatory Agents, Non-Steroidal Analgesics Peripheral Nervous System Agents Antirheumatic Agents Central Nervous System Agents |