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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00000542 |
To determine if the combined incidence of nonfatal myocardial infarction and coronary heart disease death differs between diuretic-based and each of three alternative antihypertensive pharmacological treatments. Also, to determine, in a subset of this population, if lowering serum cholesterol with a HMG CoA reductase inhibitor in older adults reduces all-cause mortality compared to a control group receiving usual care. Conducted in conjunction with the Department of Veterans' Affairs.
Condition | Intervention | Phase |
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Cardiovascular Diseases Coronary Disease Diabetes Mellitus Heart Diseases Hypercholesterolemia Hypertension Myocardial Infarction Myocardial Ischemia Heart Failure |
Drug: Inhibitors, ACE Drug: amlodipine Drug: lisinopril Drug: doxazosin Drug: chlorthalidone Drug: pravastatin Behavioral: diet, fat-restricted |
Phase III |
Study Type: | Interventional |
Study Design: | Prevention, Randomized |
Study Start Date: | August 1993 |
Study Completion Date: | March 2008 |
Primary Completion Date: | March 2008 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 55 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Men and women hypertensive patients, ages 55 and above. A total of 36 percent were diabetics.
Study ID Numbers: | 85 |
Study First Received: | October 27, 1999 |
Last Updated: | April 22, 2008 |
ClinicalTrials.gov Identifier: | NCT00000542 |
Health Authority: | United States: Federal Government |
Myocardial Ischemia Arteriosclerosis Pravastatin Necrosis Hypercholesterolemia Myocardial Infarction Dyslipidemias Arterial Occlusive Diseases Heart Failure Heart Diseases Metabolic Diseases Hyperlipidemias Lisinopril Vascular Diseases Diabetes Mellitus |
Endocrine System Diseases Ischemia Amlodipine Doxazosin Coronary Disease Calcium, Dietary Chlorthalidone Endocrinopathy Infarction Glucose Metabolism Disorders Metabolic disorder Coronary Artery Disease Hypertension Lipid Metabolism Disorders |
Antimetabolites Vasodilator Agents Molecular Mechanisms of Pharmacological Action Cardiotonic Agents Antilipemic Agents Sodium Chloride Symporter Inhibitors Diuretics Physiological Effects of Drugs Calcium Channel Blockers Enzyme Inhibitors Anticholesteremic Agents Cardiovascular Agents |
Hydroxymethylglutaryl-CoA Reductase Inhibitors Antihypertensive Agents Protective Agents Pharmacologic Actions Protease Inhibitors Membrane Transport Modulators Pathologic Processes Natriuretic Agents Therapeutic Uses Angiotensin-Converting Enzyme Inhibitors Cardiovascular Diseases |