Depression (Adult) Research Study
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Brain Imaging in Depression
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If you are currently depressed, you may be eligible to participate in a brain imaging study. This study is being conducted to try to better understand depression in major depressive disorder and bipolar disorder. These are outpatient studies requiring three to four visits. Subjects should be 18 - 60 years of age, currently depressed or have never experienced depression in the past and are otherwise medically healthy and not taking any medication. These studies include medical and psychiatric evaluations, and brain imaging. Compensation is provided.
To find out if you qualify or for more information, please call (301) 594-3186 or email us at drevetsm@mail.nih.gov.
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Protocol Information |
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Depression (Adult) Research Study
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Depression & NR2B
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If you (or someone you know) have been diagnosed with major depression, you may be able to participate in our clinical trial designed to decrease symptoms of depression and understand the causes of depression. Specifically, we are testing whether a selective NR2B antagonist, MK-0657, compared with placebo will be effective in improving overall depressive symptomatology in patients with treatment-resistant major depression.
If you are 18-55 years of age and have been diagnosed with major depression (unipolar) and have previously failed to respond to an antidepressant, you may be eligible for this inpatient clinical trial.
After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov .
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Disease and Treatment Information |
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Depression (Adult) Research Study
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NIMH FAMILY STUDY OF HEALTH AND BEHAVIOR
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The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions. We recruit people ages 21 and over with depression, manic-depression, social phobia, panic, generalized anxiety, migraine and people without any of these problems. Participants are interviewed about medical and mental symptoms and problems, their health behavior, social factors and a variety of other measures related to their health and behavior. Family members ages 8 and over will also be asked to participate. Some families will be invited to participate in further studies of biological and genetic factors.
To find out if you qualify or for more information, please call 1-877-250-1560 or email at familystudy@mail.nih.gov.
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Protocol Information |
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Depression (Adult) Research Study
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Pramipexole and Escitalopram to Treat Major Depressive Disorder
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If you (or someone you know) have been diagnosed with major depression, you may be able to participate in our clinical trial designed to decrease symptoms of depression and understand the causes of depression. Specifically, we are testing whether the combination of pramipexole (FDA approved for Parkinson's disease) with lexapro (a first line antidepressant) will improve symptoms of depression more than either drug alone.
If you are 18-65 years of age and have been diagnosed with major depression (unipolar) and have previously failed to respond to an antidepressant, you may be eligible for an outpatient or inpatient clinical trial of the combination of pramipexole with lexapro in major depression.
After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov.
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Protocol Information |
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Depression (Adult) Research Study
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Rapid Antidepressant Effects of Ketamine
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If you (or someone you know) have been diagnosed with major depression, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether ketamine, a drug that affects glutamate in the brain will improve symptoms of depression within a matter of hours.
If you are 18-60 years of age and have been diagnosed with major depression (unipolar) and previously failed to respond to treatment, you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.
After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.
To find out if you qualify or for more information, please call 1-877-MIND-NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov.
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Protocol Information |
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Depression (Adult) Research Study
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Yohimbine to Induce Rapid Antidepressant Effects
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If you (or someone you know) have been diagnosed with major depression, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether yohimbine when given at a specific time during the sleep cycle will improve symptoms of depression within a matter of hours.
If you are 18-60 years of age and have been diagnosed with major depression (unipolar), you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.
After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.
To find out if you qualify or for more information, please call 1-877 MIND NIH (1-877-646-3644) or email us at moodresearch@mail.nih.gov.
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Protocol Information |
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