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Vomiting
- Onset: <30 minutes after exposure
- Percent of victims who vomit at this dose: 100%
Diarrhea
- Heavy
- Onset: 1-3 hours after exposure
- Percent of victims with diarrhea at this dose: >10% at low end; at high end of dose range ~100% of victims affected
Headache
- Severe
- Onset: 3-4 hours after exposure
- Percent of victims with headache at this dose: 80%
Level of consciousness
Body temperature
- High fever
- Onset: < 1 hour after exposure
- Percent of victims with fever at this dose: 100%
Medical response
- Treatment in specialized hospital, if feasible
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Duration
- From end of prodrome through day ≤ 7
Epilation
- Usually complete hair loss
Medical response
- Hospitalization urgently needed
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Onset
Duration
Potential clinical effects
- Anorexia
- Fever
- Malaise, weakness
- Bleeding, infection
- Epilation: hair is lost by day 11
- Nausea, vomiting
- Diarrhea: common by day 6-9; more severe with increased exposure dose
- Disorientation
- Hypotension
Medical response
- For those with best prognosis, prolonged, aggressive supportive care, and possible hematopoietic stem cell transplant
- Supportive care for all others
Lethality
- Percent of victims who die at this dose: >50% beginning at 1-2 weeks
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Recovery
- Recovery will require prolonged, aggressive supportive care.
- All victims who recover will require continued surveillance for late effects.
- Psychological support helpful
Time to Recovery
Time to Death
- Days to weeks depending on dose and clinical complications
- Aggressive supportive care may extend survival and salvage selected patients.
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