The Biomedical Imaging Research Services Section (BIRSS) is responsible for the continued development of a sophisticated image processing and visualization application (MIPAV) that is comprehensive, extensible, and platform-independent. This application provides the foundation and tools needed to assist NIH intramural researchers with the processing of hypothesis-driven research data. Development includes the implementation of known solutions, algorithms, or methods to quickly and efficiently meet the needs of our collaborators. However, to meet unique requirements, the group develops novel methods and algorithms.