Protein Misfolding in Aging and Neurodegenerative Disease |
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| Air date: | Wednesday, March 21, 2007, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Runtime: | 74 minutes |
| NLM Title: | Protein misfolding in aging and neurodegenerative disease [electronic resource] / Richard I. Morimoto. |
| Series: | Florence S. Mahoney lecture on aging |
| Author: | Morimoto, Richard I. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2007] |
| Other Title(s): | Florence S. Mahoney lecture on aging |
| Abstract: | (CIT): Aging and stress, stress and aging - a pair of ominous human conditions that affect the quality of life. When events go awry, molecular events take place that, over time, can lead to or enhance the risk of neurodegenerative disease. At the root of problem is a fundamental process common to all cells, protein folding. When proteins misbehave and misfold, however, they can adopt altered states that cause diseases of protein conformation including the neurodegenerative Huntington's disease, Amyotrophic Lateral Sclerosis, Alzheimer's, Parkinson's and Creutzfeld-Jacob. For each, a hallmark of the disease is the appearance of misfolded and mutant proteins (Huntingtin, superoxide dismutase, amyloid beta peptide, alpha-synuclein) and associated toxicity. How these proteotoxic species form, the processes that determine their persistence or clearance, and the molecular basis of their toxicity are critical to understanding disease mechanism. WALS. |
| Subjects: | Aging--physiology Neurodegenerative Diseases--physiopathology Protein Conformation Protein Folding |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | QU 55.9 |
| NLM ID: | 101303655 |
| CIT File ID: | 13710 |
| CIT Live ID: | 5193 |
| Permanent link: | http://videocast.nih.gov/launch.asp?13710 |
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Enhanced Audio Podcast | 1:08:14 |
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Enhanced Video Podcast | 1:08:14 | |