Striatal Synaptic and Dendritic Plasticity in Parkinson's Disease – It is Not Just About Dopamine |
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| Launch in standalone player | |
| Air date: | Monday, March 12, 2007, 12:00:00 PM |
| Category: | Neuroscience |
| Runtime: | 60 minutes |
| NLM Title: | Striatal synaptic and dendritic plasticity in Parkinson's disease [electronic resource] / James Surmeier. |
| Series: | Striatal adaptations in Parkinson's disease : it's not just about dopamine |
| Author: | Surmeier, D James. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2007] |
| Other Title(s): | Striatal adaptations in Parkinson's disease : it's not just about dopamine |
| Abstract: | (CIT): Research in Dr. Surmeier's lab revolves around the question of how neuromodulators shape excitability of basal ganglia neurons. Basal ganglia is a richly interconnected set of nuclei that regulate motor and cognitive behaviors. Disorders in basal ganglia function underlie a wide variety of psychomotor disorders including Parkinson's disease, dystonia, Huntington's disease, schizophrenia and Tourette's syndrome. In many of these diseases, the principal defect appears to involve an alteration in dopaminergic signaling. The symptoms of Parkinson's disease are a consequence of the death of dopaminergic neurons that innervate one of the basal ganglia nuclei, the striatum. Major goals have been to determine how dopamine modulates the excitability of striatal neurons. Unlike classical neurotransmitters, neuromodulators like dopamine influence neuronal activity by altering the properties of voltage-dependent and ligand-gated membrane channels. Neuroscience. |
| Subjects: | Calcium Channels, L-Type Corpus Striatum--metabolism Dopamine--metabolism Neurons Parkinson Disease Synapses |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | WL 359 |
| NLM ID: | 101303641 |
| CIT File ID: | 13681 |
| CIT Live ID: | 5236 |
| Permanent link: | http://videocast.nih.gov/launch.asp?13681 |
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Enhanced Audio Podcast | 1:02:54 |
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Enhanced Video Podcast | 1:02:54 | |