Chromosome Dynamics in Cytokine Gene Expression |
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| Launch in standalone player | |
| Air date: | Wednesday, March 07, 2007, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Runtime: | 65 minutes |
| NLM Title: | Chromosome dynamics in cytokine gene expression [electronic resource] / Richard Flavell. |
| Series: | NIH director's Wednesday afternoon lecture series |
| Author: | Flavell, R A. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2007] |
| Other Title(s): | NIH director's Wednesday afternoon lecture series |
| Abstract: | (CIT): In the last few years, we have found that regulatory elements on one chromosome associate with genes on another chromosome. The system that we study is the differentiation of naïve, precursor CD4 T cells into different kinds of effector helper T cells. We first observed interchromosomal association of the TH1 ifny locus and TH2 loci, which are mutually exclusively expressed by two subtypes of differentiated T helper cells, precedes differentiation and may act as a checkpoint for T cell fate determination. Since this primary observation, we have found several other cases of into chromosomal associations between different cytokine loci in the naïve T cell precursors. Interestingly, upon TH cell differentiation, these associations are terminated and replaced by interactions between expressed loci. Regulatory elements in one locus appear to play an active role in orchestrating processes across these chromosomes. |
| Subjects: | Cell Differentiation Chromatin Cytokines--genetics Gene Expression Regulation--genetics T-Lymphocytes, Helper-Inducer--cytology |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | WH 200 |
| NLM ID: | 101303637 |
| CIT File ID: | 13673 |
| CIT Live ID: | 5191 |
| Permanent link: | http://videocast.nih.gov/launch.asp?13673 |
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Enhanced Audio Podcast | 1:04:31 |
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Enhanced Video Podcast | 1:04:31 | |