David Goldman MD., Section Chief National Institute on Alcohol Abuse and Alcoholism National Institutes of Health 5625 Fishers Lane, Room 3S-32:MSC 9412 Bethesda MD 20892-9412 telephone: +1 301.443.0059
fax: +1 301.480.2839 e-mail: David.Goldman@nih.hhs.gov
Serves as the Section Chief of Human Neurogenetics, NIAAA
Mission Statement:
Directed by David Goldman, M.D., generates the clinical dataset collections and collaborations, and encompasses the DNA/Data core, ongoing human research protocols (COMBINE, Ten Tribes Study, Alaska Native Alcohol treatment pharmacogenetics), large scale SNP detection and genotyping, in vitro and in vivo functional analyses of receptor variants, and linkage studies of markers and candidate alleles.
Current Staff:
Mary-Anne Enoch, M.D., 301.496.2727 maenoch@mail.nih.gov
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(Clinical Staff Scientist) leads population and family studies on the role of intermediate phenotypes in alcoholism. A focus of her work is electrophysiological intermediate phenotypes, particularly the low voltage alpha resting EEG trait (LVA), which she showed is more abundant in alcoholics with anxiety disorders. Psychiatric phenotype/electrophysiologic phenotype datasets Dr. Enoch developed, or for which she led electrophysiology studies, are Bethesda Caucasians, Plains Indians, and Southeastern American Indians. Dr. Enoch has studied the genetics of anxious temperament and clinical anxiety related phenotypes including OCD, Anorexia Nervosa and Seasonal Affective Disorder. Her gene findings, reported in numerous papers, include potential relationships of these phenotypes to the HTR2A gene and sex-influenced linkage of COMT Met158/Met158 to anxiety and to LVA. Recent findings include associations between GABRA2 haplotypes and alcoholism, mediated by anxiety. Dr. Enoch serves on the NIAAA IRB and is the NIAAA Women Scientists Advisor.
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Colin Hodgkinson, Ph.D., 301.443.7633 chodg@mail.nih.gov
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Joined LNG in 2003 and was appointed Staff Scientist in 2004, having previously directed a research lab located at King Faisal Hospital, Riyadh, Saudi Arabia, where he mapped monogenic neurologic diseases. He joined LNG to transition to complex disease genetics, and to lead the DNA/Data core. He is extraordinarily qualified for that role because of broad knowledge in genetics and direct experience with high throughput sequencing and genotyping, genetic linkage, and functional genetic analyses. Using the high-density haplotype approach in a large case-control dataset, Dr. Hodgkinson replicated and extended linkage of DISC 1 to schizoaffective, and is exploring the relationship of DISC 1 and genes to which it is functionally related in various phenotypes.
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Francesca Ducci, M.D., 301.443.9275 duccif@mail.nih.gov
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A Fogarty Fellow, trained in psychiatry with professors Liliana Dell’Osso and Alessandrom Rotondo (Formerly LNG) in Pisa. Dr. Ducci is interested in behavioral dyscontrol and the role of genotype in refining diagnosis. She studies phenotypes for linkage in LNG datasets most suitable for this purpose. She has constructed large SNPlex-based panels, including panels for serotonin-related genes such as. HTR1B HTR2A, and HTR2C that were previously studied at low marker density or perhaps with one functional marker, cannabinoid genes and other genes.
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Jixia Liu, Ph.D., 301.443.3227 liujixia@mail.nih.gov
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A Fogarty Research Fellow, was trained in the Neurogenetics and Human Genetics Group at Shanghai Jiaotong University where she worked on genetics of schizophrenia and previously received her Ph.D. Her main interests are in epigenetics, pharmacogenetics and array-based gene expression.
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Rickard L. Sjoberg MD., Ph.D., 301.443.3242 sjobergr@mail.nih.gov
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A special volunteer from the Centre for Clinical Research, Uppsala University, Sweden. His research interest is primarily focused on the effects of interactions between genotype, gene regulation and psychosocial stress in human and non human primates. Dr Sjoberg will primarily work with collaborative projects between LCTS and LNG.
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Qiaoping Yuan, Ph.D., 301.443.7632 Qiaoping.Yuan@nih.hhs.gov
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Is a bioinformatics and analytical IT tools resource for all members of LNG. He is in the DNA/Data Core where he leads genome informatics. He trained at NCI and joined the lab in 2005 following his work in sequencing the rice genome published in Nature at TIGR. |
Pei-Hong Shen, M.S., 301.443.7631 pshen@mail.nih.gov
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Manages all clinical genetic database and analytical IT for LNG, as described in DNA/Data Core. She is facile in database and data management tools, and in programming. She is a bioinformatics and analytical IT tools resource for all members of LNG. She joined LNG in 2004, from Celera. |
Elisa Moore 301.402.7936 lmoore@mail.nih.gov
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Systems/Network Specialist and Robotics.. She designed, installed and manages all LNG’s servers which includes a large number of DNA sequencers and dHPLC machines continually collecting data to the servers. She has also created and managed certain clinical phenotype/genotype databases. She now works on DNA robotics and other “front-end” aspects of high throughput genetic analysis. She is extremely facile in systems management, including hardware issues, and programming. |
Zhifeng Zhou, Ph.D., 301.443.9275 zhouz@mail.nih.gov
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A molecular biologist, performs all DNA sequencing and sequence variant detection in the DNA Core. In an independent project, Dr. Zhou resequenced TPH2 and found haplotype-based linkage of this gene, which encodes the rate-limiting enzyme for serotonin synthesis, to suicidality and impulsive behaviors and 5HIAA levels.
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Longina Akhtar, M.S., 301.594.3165 longina@mail.nih.gov
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An extraordinarily talented tissue culture technician, manages the front-end of multiple collaborations requiring preparation of DNA and/or lymphoblastoid cell lines. She performs or supervises all the primary cell culture, DNA extractions from cells and blood, and cell storage – including off-site backup. She assists in the construction of DNA panels for linkage studies. Her position is broad in scope and responsibility in that she is the direct, and frequent point of interaction with many collaborating investigators.
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Gary Jenkins M.S., 301.496.2117 garyj@mail.nih.gov
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A biologist technician, has a wide range of expertise in molecular biology, ranging from cloning, sequencing, and transfection and expression studies to automated genotyping. In the DNA/Data Core, he leads the clinical genotyping under CLIA (Clinical Laboratory Improvement Act) standards.
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SEARCH BY: EMPLOYEE NAME, DIVISION/BRANCH, BUILDING OR VIEW ALL NIAAA
Selected Publications: Jon-Kar Zubieta, Mary M. Heitzeg, Yolanda R. Smith, Joshua A. Bueller, Ke Xu, Yanjun Xu, Robert A. Koeppe, Christian S. Stohler, David Goldman: COMT val158met Genotype Affects mu-Opioid Neurotransmitter Responses to a Pain Stressor. Science 2003;299:1240-43 [ PDF] Michael F. Egan, Terry E. Goldberg, Bhaskar S. Kolachana, Joseph H. Callicott, Chiara M. Mazzanti, Richard E. Straub, David Goldman, and Daniel R. Weinberger: Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci 2001;98(12):6917–22. [ PDF] Ke Xu, Dirk Lichtermann, Robert H. Lipsky, Petra Franke, Xiehe Liu, Ying Hu, Liping Cao, Sibylle G. Schwab, Dieter B. Wildenauer, Claiton HD Bau, Erica Ferro, Will Astor, Thembi Finch, Jeanietta Terry, Julie Taubman, Wolfgang Maier, David Goldman: Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry 2004;61(6):597-606 [ PDF] Ahmad R. Hariri, Venkata S. Mattay, Alessandro Tessitore, Bhaskar Kolachana, Francesco Fera, David Goldman, Michael F. Egan, Daniel R. Weinberger: Serotonin transporter genetic variation and the response of the human amygdala. Science 2002;297(5580):400-3. [ PDF]
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NIH Research and Training Opportunities
Updated: June 2007
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