Laboratory of Molecular Physiology
Steven S. Vogel
Education
The City College of New York:
B.S. in Biology, 1978, Cum Laude.
Columbia University:
M.A. in Biochemistry & Molecular Biophysics, 1984,
M. Phil. in Biochemistry & Molecular Biophysics, 1988
Ph.D. in Biochemistry & Molecular Biophysics, 1989
Research Interests
My general areas of interest are the physiology and biophysics of biological membranes. The problems that I have been studying are the mechanism & regulation of calcium triggered exocytosis, and the coupling mechanism of exocytosis to compensatory endocytosis. My laboratories current specific aim is to understand how integral membrane proteins, such as ion channels and receptors, are targeted to and maintained in specific cell-surface microdomains. Our approach is to use multiphoton laser scanning microscopy (MPLSM), spectral imaging, fluorescent lifetime imaging (FLIM), fluorescence resonance energy transfer imaging (FRET), and computational modeling & analysis, in conjunction with standard cell & molecular biological methods to study membrane trafficking in living cells and organisms.
Selected Publications
Frejtag W, Burnette J, Kang B, Smith RM, Vogel SS. An increase in surface area is not required for cell division in early sea urchin development. Dev Biol. 2003 Jul 1;259(1):62-70. 
Bansal D, Miyake K, Vogel SS, Groh S, Chen CC, Williamson R, McNeil PL, Campbell KP. Defective membrane repair in dysferlin-deficient muscular dystrophy. Nature. 2003 May 8;423(6936):168-72.
McNeil PL, Miyake K, Vogel SS. The endomembrane requirement for cell surface repair. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4592-7. Epub 2003 Apr 02.
Smith RM, Baibakov B, Lambert NA, Vogel SS. Low pH inhibits compensatory endocytosis at a step between depolarization and calcium influx. Traffic. 2002 Jun;3(6):397-406.
Ikebuchi Y, Baibakov B, Smith RM, Vogel SS. Plasma membrane resident 'fusion complexes' mediate reconstituted exocytosis. Traffic. 2001 Sep;2(9):654-67.
Blank PS, Vogel SS, Malley JD, Zimmerberg J. A kinetic analysis of calcium-triggered exocytosis. J Gen Physiol. 2001 Aug;118(2):145-56.
Huang H, Vogel SS, Liu N, Melton DA, Lin S. Analysis of pancreatic development in living transgenic zebrafish embryos.Mol Cell Endocrinol. 2001 May 25;177(1-2):117-24.
Jessen JR, Jessen TN, Vogel SS, Lin S. Concurrent expression of recombination activating genes 1 and 2 in zebrafish olfactory sensory neurons. Genesis. 2001 Apr;29(4):156-62.
McNeil PL, Vogel SS, Miyake K, Terasaki M. Patching plasma membrane disruptions with cytoplasmic membrane. J Cell Sci. 2000 Jun;113 ( Pt 11):1891-902.
Smith RM, Baibakov B, Ikebuchi Y, White BH, Lambert NA, Kaczmarek LK, Vogel SS. Related Articles, Links Exocytotic insertion of calcium channels constrains compensatory endocytosis to sites of exocytosis. J Cell Biol. 2000 Feb 21;148(4):755-6
Mailing Address
Acting Chief, Section On Cellular Biophotonics
DHHS/NIH/NIAAA/DICBR/LMP
Park Bldg rm. 158G
12420 Parklawn Dr.
MSC 8115
Rockville, MD 20892-8115
Office phone: (301) 496-9288
Lab phone: (301) 443-4608 & -4610
FAX: (301) 480-1734
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