Mission Statement:
The Laboratory of Molecular Physiology focuses on investigating molecular mechanisms underlying neurotransmitter-mediated modulation of voltage-gated ion channels. Studies will focus on
- defining molecular mechanisms underlying modulation of N-type Ca2+ channels in sympathetic neurons, mediated by the heterotrimeric G-protein Bg subunit;
- understanding the role and function of metabotropic glutamate receptors (mGluRs) and, metabotropic GABA receptors; and
- analyzing the function of a tetrodotoxin (TTX)-resistant voltage-gated Na+ channel found in primary sensory neurons and involved in pain transmission.
These research directions will be integrated into an alcohol-related program by extending this work into CNS synaptic systems. The Laboratory trains research investigators in the techniques utilized to conduct its research and collaborates with other components of the Institute, NIH, other Federal agencies, universities, and other scientific institutions working in these areas.
LMP Components:
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NIH Research and Training Opportunities
Updated: October 2005