Mission Statement:
This section develops new rapid throughput methods for the analysis of intermediary metabolites in animal and human tissues. It defines the kinetic and thermodynamic constants responsible, and the mathematical approaches required to define the changes in flux control resulting in the alteration of fluxes in metabolic pathways involved in disease states and develops new therapeutic approaches based on these analyses. It then tests the efficacy of these new therapies in animal models and in specific human disease states including neurodegenerative diseases, movement disorders, insulin resistant states and refractory epileptic states.
Staff:
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Selected Publications:
Stark KD, Pawlosky RJ, Beblo S, Murthy M, Flanagan VP, Janisse J, Buba-Abela M, Rockett H, Whitty JE, Sokol RJ, Hannigan JH, Salem N Jr. Post-fortification plasma folate status in pregnant African-American women and the influences of diet, smoking and alcohol consumption (AJCN) 00:2005. 
Pawlosky RJ and Salem N Jr. Development of alcoholic fatty liver and fibrosis in rhesus monkeys fed a low n-3 fatty cid diet. Alcoholism: Clin and Exp Res. 2004; 28:1569-1576.
Pawlosky RJ. Modeling linolenic and linoleic acid in human adults and infants. In: Mathematical Modeling. Nutritional and Health Sciences. 2004.
Pawlosky RJ and Salem N Jr. Perspectives on Alcohol Consumption: Liver Polyunsaturated Fatty Acids and Essential Fatty Acid Metabolism. Alcohol. 2004; 34:27-33.
Pawlosky R.J., Novotny J.A., Britz S.J. and Clevidence B.A. Methods for determining the metabolism of alpha-linolenic acid in human subjects from intrinsically-labeled food. Modern Aspects of Nutrition. Present Knowledge and Future Perspectives. 2003; 56:170-175.
Pawlosky R.J., Hibbeln, J.R., Lin YH. and Salem N. Jr. Effects of beef- and fish-based diets on the kinetics of n-3 fatty acid metabolism. Am J Clin Nutr. 2003; 77:565-72.
Thomas PM, Flanagan, VP, Pawlosky RJ. Determination of 5-methyltetrahydrofolic acid and folic acid in citrus juices using stable isotope dilution-mass spectrometry. J Agric Food Chem. 2003; 51:1293-6.
Alcohol publications can also be found using ETOH Database
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