LMBB - Unit of Metabolic Control

Mission Statement:

Plans and conducts investigation on the effect of alcohol on cell structure and function at the molecular level;
investigates the molecular mechanisms involved in the development of alcoholism and alcohol-induced pathologies;
trains investigators in research approaches to alcohol abuse and alcoholism;
collaborates with organizations outside of the Institute in studies related to the effects of alcohol abuse on molecular mechanisms, and
studies the effects of ethanol and its metabolites on the processes which control metabolism.

Staff:

Name	Title	E-Mail	Phone
Dr. Richard L. Veech	Chief, Sup Med Off (Res)	rveech@mail.nih.gov	301.443.4620
Calvin Crutchfield	Biol. Sci. Lab. Tech	calvinc@niaaa.nih.gov	301.496.6223
Dr. Robert Pawlosky	Staff Scientist	bpawl@mail.nih.gov	301.443.9031
Dr. Yosihiro Kashiwaya	Research Fellow	kashi@mail.nih.gov	301.496.3063

Selected Publications:

Cascante M, Centelles JJ, Veech RL, Lee WN, Boros LG. Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation. Nutr Cancer 2000; 36 :150-4. [ PDF ]

Jeong KS, Park SJ, Lee CS, Kim TW, Kim SH, Ryu SY, Williams BH, Veech RL, Lee YS. Effects of cyclocreatine in rat hepatocarcinogenesis model. Anticancer Res 2000; 20 :1627-33.

Kashiwaya Y, Takeshima T, Mori N, Nakashima K, Clarke K, Veech RL. D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc Natl Acad Sci U S A 2000; 97 :5440-4. [ PDF ]

Kashiwaya Y, King MT, Veech RL: Substrate signaling by insulin: a ketone bodies ratio mimics insulin action in heart. Am J Cardiol 1997; 80 :50A-64A.

Kashiwaya Y, Sato K, Tsuchiya N, Thomas S, Fell DA, Veech RL, Passonneau JV: Control of glucose utilization in working perfused rat heart. J Biol Chem 1994 Oct 14; 269:25502-14.

Sato K, Kashiwaya Y, Keon CA, Tsuchiya N, King MT, Radda GK, Chance B, Clarke K, Veech RL: Insulin, ketone bodies, and mitochondrial energy transduction. FASEB J 1995 May; 9:651-8.

Veech RL, Chance B, Kashiwaya Y, Lardy HA, Cahill GF Jr. Ketone bodies, potential therapeutic uses. IUBMB Life. 2001; 51 :241-7. Review. [ PDF ]

Veech RL, Fell DA: Distribution control of metabolic flux. Cell Biochem Funct. 1996; 14 :229-36.

Veech RL: Physiological approaches to increase biocompatibility of peritoneal dialysis. Perit Dial Int. 1996; 16 :332-3.

Veech RL, Kashiwaya Y, King MT: The resting membrane potential of cells are measures of electrical work, not of ionic currents. Integr Physiol Behav Sci. 1995 Sep-Dec; 30 :283-307.

Alcohol publications can also be found using ETOH Database

Updated: July 2004