Creutzfeldt Jakob disease
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Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, invariably fatal brain disorder. It affects about one person in every one million people per year worldwide. CJD usually appears in later life and runs a rapid course. Typically, onset of symptoms occurs about age 60, and about 90 percent of patients die within 1 year. In the early stages of disease, patients may have failing memory, behavioral changes, lack of coordination and visual disturbances. As the illness progresses, mental deterioration becomes pronounced and involuntary movements, blindness, weakness of extremities, and coma may occur.[1]
CJD belongs to a family of human and animal diseases known as the transmissible spongiform encephalopathies (TSEs). Spongiform refers to the characteristic appearance of infected brains, which become filled with holes until they resemble sponges under a microscope. CJD is the most common of the known human TSEs. Other human TSEs include kuru, fatal familial insomnia (FFI), and Gerstmann-Straussler-Scheinker disease (GSS).[1]
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The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Creutzfeldt Jakob disease. Click on the link to go to OMIM and review these resources.
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ClinicalTrials.gov lists trials that are studying or have studied Creutzfeldt Jakob disease. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
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