Diabetes Unit: Selected Recent Publications

Muniyappa R, Hall G, Kolodziej TL, Karne RJ, Crandon SK, Quon MJ. Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension. Am J Clin Nutr. 2008 Dec;88(6):1685–96.
Chen H, Lin AS, Li Y, Reiter CE, Ver MR, Quon MJ. Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion. J Biol Chem. 2008 Oct 24;283(43):29228–38.
Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E15—26.
Collins QF, Liu HY, Pi J, Liu Z, Quon MJ, Cao W. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinase. J Biol Chem. 2007 Oct 12;282(41):30143–9.
Muniyappa, R., Montagnani, M., Koh, K.K., Quon, M.J.: Cardiovascular actions of insulin. Endocrine Reviews. 2007 Aug;28(5):463–91.
Kim, J., Montangnani, M., Formoso, G., Li, Y., Koh, Y., Chung, A., Quon, M.J.: Epigallocatechin gallate , a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium involving Fyn, PI 3-kinase, Akt, and eNOS. Journal of Biological Chemistry 282:13736–13745, 2007.
Potenza, M.A., Marasciulo, F.L., Tarquinio, M., Tiravanti, E., Colantuono, G., Federici, A., Kim, J., Quon, M.J., Montagnani, M.: Epigallocatechin gallate, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial ischemia/reperfusion injury in Spontaneously Hypertensive Rats (SHR). American Journal of Physiology—Endocrinology and Metabolism, 292:E1378–E1387, 2007.
Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 2006 Apr 18;113(15):1888–904.
Chen H, Karne RJ, Hall G, Campia U, Panza JA, Cannon RO III, Wang Y, Katz A, Levine M, Quon MJ. High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance. American Journal of Physiology. Heart and Circulatory Physiology. 2006;290(1):H137–145.
Formoso G, Chen H, Kim JA, Montagnani M, Consoli A, Quon MJ. DHEA mimics acute actions of insulin to stimulate production of both NO and ET-1 via distinct PI 3-kinase- and MAP-kinase-dependent pathways in vascular endothelium. Molecular Endocrinology 20:1153–63, 2006.
Muniyappa, R., Karne, R.J., Hall, G., Crandon, S.K., Bronstein, J.A., Ver, M.R., Hortin, G.L., Quon, M.J.: Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects. Diabetes 55:3142–3150, 2006.
Chen H, Sullivan G, Quon MJ. Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model. Diabetes. 2005;54:1914–1925.
Kim J, Yeh DC, Ver M, Li Y, Carranza MA, Conrads TP, Veenstra TD, Harrington M, Quon MJ. Phosphorylation of Ser24 in the PH domain of IRS-1 by mPLK/IRAK: cross-talk between inflammatory signaling and insulin siganling that may contribute to insulin resistance. Journal of Biological Chemistry. 2005;280:23173–23183.
Potenza MA, Marasciulo FL, Mitolo Chieppa D, Quon MJ, Montagnani M. Insulin resistance in spontaneously hypertensive rats (SHR) is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production. American Journal of Physiology. Heart and Circulatory Physiology. 2005;March 25.
Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. Journal of Biological Chemistry. 2003;278(45):45021–45026.
Montagnani M, Ravichandran LV, Chen H, Esposito DL, Quon MJ. Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells. Molecular Endocrinology. 2002;16(8):1931–1942.
Sedaghat AR, Sherman A, Quon MJ. A mathematical model of metabolic insulin signaling pathways. American Journal of Physiology—Endocrinology and Metabolism. 2002;283(5):E1084–E1101.
Montagnani M, Chen H, Barr VA, Quon MJ. Insulin-stimulated activation of eNOS is independent of Ca++ but requires phosphorylation by Akt at Ser1179. Journal of Biological Chemistry. 2001;276(32):30392–30398.
Ravichandran LV, Esposito DL, Chen J, Quon MJ. Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin. Journal of Biological Chemistry. 2001;276(5):3543–3549.
Katz A, Nambi S, Mather K, Baron AD, Follman DA, Sullivan G, Quon MJ. Quantitative insulin-sensitivity check index (QUICKI): a simple, accurate method for assessing insulin sensitivity in vivo. Journal of Clinical Endocrinology and Metabolism. 2000;85(7):2402–2410.
Zeng G, Nystrom FH, Ravichandran LV, Cong L, Kirby M, Mostowski H, Quon MJ. Roles for insulin receptor, PI 3-kinase, and Akt in insulin signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation. 2000;101(13):1539–1545.
Chen H, Wertheimer SJ, Lin CH, Katz SL, Amrein KE, Burn P, Quon MJ. Protein tyrosine phosphatases PTP1B and Syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Journal of Biological Chemistry. 1997;272(12):8026–8031.
Zeng G, Quon MJ. Insulin-stimulated production of nitric oxide is inhibited by wortmannin: direct measurement in vascular endothelial cells. Journal of Clinical Investigation. 1996;98(4):894–898.