| | Principal Investigators
| Lee E. Eiden,
Ph.D. |
 |
|
Dr.
Eiden is chief of the Section
on Molecular Neuroscience in the NIMH Intramural
Research Program (IRP). He received his undergraduate
degree in chemistry at Northwestern University, his
doctoral degree in pharmacology at The University of
Kansas, and joined the Unit on Neuroendocrinology in
the Laboratory of Clinical Science in the NIMH-IRP in
1979. Dr. Eiden currently serves on the editorial boards
of The Journal of Biological Chemistry and The Journal
of Molecular Neuroscience. |
| Research Interests |
| Members
of the Section on Molecular Neuroscience study neuropeptide slow transmission,
and trans-synaptic signaling leading to cellular plasticity,
mainly at the adrenomedullary synapse. One of the Section's
major working hypotheses is that combinatorial signaling
by neuropeptide transmitters is an important component
of central and peripheral nervous system cellular plasticity
during adaptation to new metabolic and environmental
states. The section is conducting a species-comparative study of neuropeptide signaling
through G-protein coupled receptors that will contribute to the understanding of
how slow transmission encodes experience in the central and peripheral nervous
systems. |
| Representative Selected Recent Publications: |
- Vaudry D, Hamelink C, Damadzic R, Eskay RL, Gonzalez B, Eiden LE:
Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult.
Peptides, 26: 2518-2524, 2005. (View PDF)
- Hamelink C, Hahm SH, Huang H, Eiden LE:
A restrictive element 1 (RE-1) in the VIP gene modulates transcription in neuronal and non-neuronal cells in collaboration with an upstream tissue specifier element.
Journal of Neurochemistry, 88: 1091-1101, 2004. (View PDF)
- Schultz B, Damadzic R, Weihe E, Eiden LE:
Identification of a region from the human cholinergic gene locus that targets expression of the vesicular acetylcholine transporter to a subset of neurons in the medial habenular nucleus in transgenic mice.
Journal of Neurochemistry, 87: 1174-1183, 2003. (View PDF)
- Vaudry D, Stork PJS, Lazarovici P, Eiden LE:
Signaling pathways for PC12 cell differentiation: making the right connections. Science 296: 1648-1649, 2002. (View PDF)
- Hamelink C, Lee H-W, Chen Y, Grimaldi M, Eiden LE:
Coincident elevation of cAMP and calcium influx by PACAP-27 synergistically regulates vasoactive intestinal polypeptide gene transcription through a novel PKA-independent signaling pathway.
Journal of Neuroscience, 22: 5310-5320, 2002. (View PDF)
- Hamelink C, Tjurmina O, Damadzic R, Young WS, Weihe E, Lee H-W, Eiden LE:
Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis.
Proceedings of the National Academy of Sciences USA, 99: 461-466, 2002. (View PDF)
|
Address:
|
Dr.
Lee E. Eiden
Molecular Neuroscience Section
Laboratory of Cellular and Molecular Regulation
Building 36, Room 3A19
36 Convent Drive MSC 4091
Bethesda, MD 20892-4091 |
| Phone: |
301) 496-4110 |
| Email Dr. Eiden |
| Fax: |
(301) 402-1748 |
| Lab Web Site: |
http://intramural.nimh.nih.gov/lcmr/smn/ |
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