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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Principal Investigators Jun Shen, Ph.D.   Dr. Shen is chief of the Magnetic Resonance Spectroscopy Core Facility Mood & Anxiety Disorders Program of the Intramural Research Program, National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland. He also directs the Magnetic Resonance Spectroscopy Core Facility. He attended college at Nankai University and graduate school at Nankai University and University of Wisconsin at Madison. He did postdoctoral research in molecular biochemistry and biophysics at Yale University School of Medicine. He joined NIMH in 2002. His previous work involved in vivo magnetic resonance spectroscopy technology and applications with a focus on measuring glutamate and GABA. Prior to joining NIMH, he received a NARSAD Young Investigator Award. Research Interests Dr. Shen’s research at the NIMH focuses on non-invasive in vivo magnetic resonance spectroscopy and imaging technology development and applications. Magnetic resonance spectroscopy (MRS) allows detection of concentration of many chemicals (e.g., glutamate and GABA) in vivo, which may be used as important disease markers. Using carbon-13 MRS, certain metabolic fluxes can also be measured. The recent discovery of carbon-13 magnetization transfer effect by Dr. Shen and colleagues has extended the scope of carbon-13 MRS to include measurement of fluxes catalyzed by specific enzymes in vivo. Dr. Shen’s group is interested in applying advanced proton and heteronuclear magnetic resonance spectroscopic imaging techniques to studying chemical pools, fluxes and enzyme reactions in normal brain function and in neuropsychiatric disorders. Representative Selected Recent Publications: J Yang, S Singh, and J Shen, 13C saturation transfer effect of carbon dioxide-bicarbonate exchange catalyzed by carbonic anhydrase in vivo, Magn Reson Med, in press. S Li, J Yang, and J Shen, Novel strategy for in vivo cerebral 13C MRS using very low RF power for proton decoupling, Magn Reson Med, 57:265-271, 2007. S Xu, J Yang, and J Shen, In vivo 13C saturation transfer effect of the lactate dehydrogenase reaction, Magn Reson Med, 26;57:258-264, 2007. G Hasler, JW van der Veen, T Tumonis, N Meyers, J Shen, and WC Drevets, Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined by proton magnetic resonance spectroscopy, Arch Gen Psychiatry, 64:193-200, 2007. I-Y Choi, S-P Lee, H Merkle, and J Shen, In vivo detection of gray and white matter differences in GABA concentration in the human brain, NeuroImage, 33:85-93, 2006. Address: MIB/MADP/NIMH Bldg. 10, Rm. 2D51A 9000 Rockville Pike, MSC 1527 Bethesda, MD 20892-1527 Phone: 301-451-3408 Email Dr, Shen Fax: 301-480-2397 Lab Web Site: No Website Available     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Staff Scientists/Clinicians Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Non-Human Primate Core Scientific and Statistical Computing Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.