| Explains procedures for writing an application and then
applying for and maintaining an NIH grant application for research that
uses animals.
This is the print-friendly version. We update it monthly. For the most current information, read the page-by-page tutorial. You can also visit our other All About Grants Tutorials.
Table of Contents
- Requirements
for Grantees Using Research Animals
- Research
Planning Is a Team Effort
- Consider
Alternatives to Using Animals
- Is
Your Institution Assured by OLAW?
- How
to Get an Assurance
- What OLAW Looks For
- Veterinary
Care
- Personnel
Qualifications and Training
- Occupational
Health and Safety
- Animal
Facilities and Species Inventory
- Working
With Your IACUC
- How
Your IACUC Is Structured
- Write
Your Protocol
- Write
the Application: Indicate Use of Animals
- Answer
the Five Points in the Vertebrate Animals Section
- How NIAID Reviews Applications Using Research Animals
- Understand
Codes on Your Summary Statement
- NIAID
Will Send a Just-in-time Request
- Reporting
Requirements During Your Award
- IACUCs
Monitor Your Progress
- You'll
Have Semiannual Reviews and Inspections
- Avoid
Suspension of Animal Activities
- Know
Your IACUC's Reporting Requirements
- Keep
Your Records Accessible
- In
Conclusion
Requirements
for Grantees Using Research Animals
If you are a principal
investigator planning to use live, vertebrate animals
for research, research
training, or biological testing, you must adhere to requirements
in the Public
Health Service (PHS) Policy on Humane Care and Use of Laboratory
Animals and the Animal
Welfare Act and Regulations.
The PHS policy is summarized in the brochure What Investigators Need to Know About the Use of Animals.
Read about NIH animal research, policies, and crisis management at OER Animals in Research.
Peer
reviewers will evaluate your application based on your compliance,
so it's important to know what's expected of you and your institution.
When you apply for NIAID funding, you need answer all five points in the Vertebrate Animals Section of your Grant
Application Package (for electronic applications) or your PHS
398 (for paper applications). Most grant types, including research grants such as the R01 and Exploratory/Developmental Grant -- R21, use electronic application, but training (T), career (K), and fellowship (F) grants still use paper forms.
Go to our NIH Grant Cycle: Application to Renewal for beginning-to-end, step-by-step information about applying for the most common grant types.
If your application receives a fundable priority score, have your animal use protocol reviewed
and approved by an institutional
animal care and use committee (IACUC), which evaluates your institution's
animal research program.
To receive an award, you must have IACUC approval, and
your institution must have an animal
welfare assurance approved by the NIH Office
of Laboratory Animal Welfare. If you have domestic subaward agreements, those organizations also need IACUC approval and an animal welfare assurance.
For foreign awards and subawards, learn more at IACUC Requirements Vary for Domestic and Foreign Institutions.
To find out if your institution is assured, see Domestic
Institutions with a PHS Approved Animal Welfare Assurance or Foreign
Institutions with a PHS Approved Animal Welfare Assurance on
the OLAW Web site. Assurances must be renewed every four years.
It's also a good idea to find out if your institution has animal facilities
accredited by the Association for
Assessment and Accreditation of Laboratory Animal Care.
AAALAC is a non-regulatory organization; participation in its accreditation
program sends the message that your institution is committed to high-quality
animal care and use.
Resources
Research
Planning Is a Team Effort
Planning and teamwork are key to preparing a successful application.
An animal research application requires a lot of work, so start early,
leave time for unanticipated issues, and involve experts in your project
from the beginning.
Ask senior IACUC members
to validate your ideas and methods. Consult with the attending veterinarian
about available facilities, equipment, personnel, and products.
For
example, the veterinarian may know of a new analgesic that introduces
fewer variables into the research. The institutional
business official who signs your grant application should also
be comfortable with your proposal.
These early consultations protect you and your institution.
Since NIH allows just-in-time IACUC
approval of animal use protocols,
a PI can
move a research project all the way through NIH initial
peer review before an IACUC has a chance to see it.
If your IACUC
has last minute problems with your protocol, e.g., you have no biosafety
level four facilities to inject mice with Ebola virus, you might
not receive funding you otherwise could have received.
See NIAID's NIH Grant Cycle: Application to Renewal for more tips and
advice on organizing and conveying your ideas.
Resources
Consider
Alternatives to Using Animals
When
planning your research, consider whether you can achieve your scientific
objectives while reducing the number of animals, refining the use of
animals by minimizing their pain or distress, or even better, not using
them
at
all.
USDA regulations
require that investigators search the scientific literature for alternatives,
but if this isn't done until the IACUC approval
stage, most researchers will have already determined
what animals they are going to use and how.
Considering alternatives during the planning stage gives you enough
time to incorporate methods that benefit the animals and the science.
It also shows peer
reviewers that you are thorough and reduces your chances of
a bar
to award because of animal
welfare concerns.
Limit Animal Use and Discomfort
- Limit animal involvement by using
the minimum number required to obtain valid results.
- Use non-animal
methods, such as mathematical models, computer simulation, or in vitro biological
systems.
- Avoid or minimize animal discomfort, distress, and pain
as is consistent with sound scientific practices.
- Use appropriate
sedation, analgesia, or anesthesia when your procedures will cause
more than momentary pain or distress. Do not perform surgical
or other painful procedures on non-anesthetized animals.
Resources
Is
Your Institution Assured by OLAW?
Before
NIAID can award your grant, your institution and
all performance sites involved in animal work must have an animal
welfare assurance on file with OLAW.
There are three types of assurances: full, inter-institutional, and
foreign.
- Full assurances are for domestic institutions
that control their own facilities and have a complete
animal care and use program in place,
including a veterinarian and IACUC.
Full assurances remain in effect for four years and can be resubmitted
for an additional four years.
- Inter-institutional assurances are for organizations that contract
animal work to an assured institution or use its facilities. The organizations agree to conduct the project according to the assurance of the covered organization. Timeframes
for these agreements are project specific. For example, a small
business subcontracting animal work to a performance site must
reapply for an inter-institutional assurance each time it competes
for a grant.
- Foreign assurances are for foreign institutions that are grantees or subaward partners to a domestic grantee. A foreign entity must state that it will comply with either animal welfare requirements for domestic
institutions or the laws and regulations of the country in which it resides. For example, a German institution or performance site
could adhere to German laws for animal care and use. Foreign assurances
are in effect for five years.
Institutions that collaborate with grantees through a subaward also require assurances. Alternatively, a grantee may amend its assurance to cover a collaborating institution.
Resources
How
to Get an Assurance
If your institution has
never had an assurance,
don't worry about it when you apply. NIAID grants
management or program staff
will contact OLAW to
negotiate an assurance with your institution if you're likely to be
funded based on peer
review results, e.g., your percentile or priority score is
within NIAID's payline.
For that process, OLAW will send your institution a packet that includes
a sample assurance and PHS policy
information. IACUC members
and other experts at your institution should collaborate to draft the
assurance, inserting your institution's animal policies and procedures
where appropriate. Follow the format shown at OLAW's Sample Animal Welfare
Assurance.
Your institution will designate an institutional
official for animal welfare, who signs the assurance and sends
it to OLAW using either of these methods:
- Email. Send the signed assurance to olawdoa@mail.nih.gov as a PDF attachment.
- Postal mail. Send the signed assurance to the following address:
Office of Laboratory Animal Welfare
RKL1, Suite 360, MSC 7982
6705 Rockledge Drive
Bethesda, MD 20892-7982 (Use this ZIP code for the U.S. Postal Service, including express mail.)
Bethesda, MD 20817 (Use this ZIP code for commercial carriers such as FedEx and UPS.)
Do not include attachments for the following documents: resumes of the veterinarian or IACUC members, description of the institutional occupational health and safety program, or description of the animal care and use training program.
OLAW will review your institution's assurance for compliance with
federal policies. If acceptable, OLAW signs it and your institution
is assured. If not, OLAW will prompt your institution for more information
until satisfied with the response. Your application is barred
from an award until an assurance is in place.
When reviewing your institution's animal
welfare assurance, OLAW will
evaluate several items, including veterinary care, personnel qualifications
and training, occupational health and safety, and animal facilities
and husbandry.
Resources
What OLAW Looks For: Veterinary
Care
All
veterinary programs must provide for the following.
- Access to animals and periodic assessment of their well-being.
- Appropriate
facilities, personnel, equipment, and services.
- Treatment of diseases
and injuries and the availability of emergency, weekend, and holiday
care.
- Guidelines for animal procurement and transportation.
- Preventive
medicine.
- Pre-surgical planning, training, monitoring, and post-surgical
care.
- Pain relief, including analgesics, anesthetics, and tranquilizers.
- Euthanasia. Follow the American Veterinary Medical Association Guidelines on Euthanasia.
- Drug storage and control.
The attending veterinarian must have the authority to implement the
veterinary care program and oversee the adequacy of other aspects of
animal care and use, e.g., animal husbandry, nutrition, sanitation
practices, and hazard containment.
The size of the veterinary staff depends on the institution and the
size and nature of its animal program. Consultant or part-time veterinary
services may be appropriate for small programs with limited numbers
of animals.
Do not include the veterinarian's resume as an assurance attachment. Instead, describe the veterinarian's qualifications in the assurance form. Follow the format shown on OLAW's Sample Animal Welfare
Assurance.
Resources
Personnel
Qualifications and Training
Your institution must
ensure that staff working with animals are qualified and train investigators
on policies and means to minimize animal pain and distress.
Do not include an assurance attachment to describe the animal care and use training program. Instead, describe the program in the assurance form. Follow the format shown on OLAW's Sample Animal Welfare
Assurance.
For more information, read Education
and Training in the Care and Use of Laboratory Animals: A Guide
for Developing Institutional Programs, developed by the Institute for Laboratory Animal Research.
Resources
Occupational
Health and Safety
OLAW makes
sure your institution has an occupational health and safety program
for all personnel who work with animals. The program will depend on
the facility, research activities, hazards, and animal species involved.
Minimally, the program should include the following.
- Pre-placement medical evaluation.
- Identification of hazards and
safeguards against risks.
- Appropriate testing and vaccinations.
- Staff training on hazards,
safeguards, and roles and responsibilities.
- Policies and facilities
that promote cleanliness and safety.
- Provisions for documenting
and treating job-related injuries and illnesses.
Do not include an assurance attachment to describe the occupational health and safety program. Instead, describe the program in the assurance form. Follow the format shown on OLAW's Sample Animal Welfare
Assurance.
For guidelines on establishing and maintaining an effective safety
program, check out Occupational Health and Safety
in the Care and Use of Research Animals, published by the National Research Council.
Resources
Animal
Facilities and Species Inventory
Institutions
provide a facility and species inventory as part of their assurance. Follow the format shown on OLAW's Sample Animal Welfare
Assurance.
OLAW uses
this information to assess the nature and size of the animal care and
use program and evaluate the adequacy of other program components,
e.g., veterinary care, occupational health, and safety.
Resources
Working
With Your IACUC
Your IACUC is
an oversight body appointed by an official at your domestic institution, such
as the chief executive
officer. The Office
of Laboratory Animal Welfare relies on the IACUC to enforce PHS policy
and your institution's animal policies.
IACUCs do the following:
- Review and approve animal use protocols,
including significant changes to previously approved
protocols.
- Monitor
your animal care and use program, including a semi-annual inspection
of animal facilities.
- Hold orientation programs on institutional animal
policies and procedures, e.g., what is expected, which protocol
forms to use, and
where to get animals.
- Evaluate compliance with institutional policies.
- Report
annually and notify OLAW of
suspensions and instances of serious noncompliance with policy. See the February 24, 2005, Guide notice for guidance on what an IACUC should report to OLAW.
Find out your institution's policies before you plan your research.
In most institutions, policies for research animals are a combination
of institutional and USDA and PHS requirements.
Some are more stringent than others, so a procedure you performed at
another institution may not be acceptable at your current workplace.
IACUC Requirements Vary for Domestic and Foreign Institutions
Identify your situation below for a summary of IACUC requirements.
- Domestic grantees with no foreign subawards
- Follow all the IACUC requirements outlined in this tutorial and by OLAW.
- Domestic grantees with a foreign subaward
- The domestic institution's IACUC reviews and approves the animal protocol in the application.
- Both institutions must have an OLAW assurance.
- The foreign subawardee should also follow the instructions in the next section.
- Foreign grantees
and subawardees
- Your institution doesn't need its own IACUC unless required by local law.
- Your institution must have an OLAW assurance.
- You must complete a “Statement of Compliance with Standards for Humane Care and Use of Laboratory Animals by Foreign Institutions.”
Resources
How
Your IACUC Is Structured
Your IACUC will
have at least five members, including people with the following backgrounds.
- A veterinarian with experience in laboratory animal science
and medicine, who has direct or delegated authority and responsibility
for activities involving animals at the institution.
- A practicing
scientist experienced in research with animals.
- A person whose primary
concerns are in a nonscientific area, e.g., an ethicist, lawyer,
or member of the clergy.
- A person not affiliated with the institution
who represents community interests and who is not a laboratory
animal user.
Other IACUC members are usually faculty members and fellow researchers
who are familiar with the issues you are facing and can serve
as resources to help you prepare the best possible application.
Resources
Write
Your Protocol
Coordinate
writing your application and protocol. Be sure to write your protocol
early enough for the IACUC.
It is extremely important that the information in the protocol submitted
to the IACUC is consistent with the information in your grant application.
Most IACUCs require investigators to submit information about proposed
animal
use
on an institutional
protocol
review
form. Before
writing your protocol,
consult with the attending veterinarian on the latest technologies
and procedures that could improve your approach. Also send the veterinarian
a draft of your protocol to resolve any issues before it goes to
the IACUC.
A standard animal protocol includes the following information.
- Description of project. Help IACUC members understand your animal
procedures by avoiding technical language only people in your field
will understand. Use visual aids, such as flow charts and bullets,
to illustrate your points or break up text.
- Justification for using
animals. Describe why an animal model is
necessary. If you're
studying a human health problem, state its cause, existing therapies,
and
the potential
contribution
of your experiments to further its understanding. Use lay language,
explaining all medical terms and defining acronyms the first time
you use them.
- Justification for species. Tell IACUC
members why you chose one species over others. You should generally
use the most appropriate and least
sentient species
capable of providing the data you need. The following is a typical
hierarchy of sentient animal species.
- Non-human primates, such as monkeys, marmosets, and
baboons.
- Large animals, such as cats, dogs, and pigs.
- Rabbits.
- Rodents, such as hamsters, rats, and mice.
- Non-mammalian vertebrates, such as poultry, reptiles, and
fish.
Your rationale for using a species may be size, availability, or cost;
the existence of previous work or laboratory data that validates the
use of a certain animal model; or the availability of reagents.
- Justification for number of animals. Request the amount of animals
you need and explain why. Use the minimum number needed to yield
statistically significant results.
- Consideration of alternatives. Convince
IACUC members that you have adequately explored alternative methods.
Use techniques to minimize pain and distress.
These are known as "refinements" to your protocol. List databases
you searched and when, citations derived,
and the
keywords
or search strategy. List other sources, such as journal articles,
presentations, and colleagues.
- Description of animal procedures. Include non-surgical methods, such as injections and sample collections;
surgical methods,
such as
suturing and anesthesia; and other measures, such as pre-anesthetic
fasting, drugs, and care during recovery.
- Assurance that qualified
staff will perform work. Name all personnel who will be working
on your study, along with their animal
research
experience and familiarity with your proposed procedures. If you
or someone on your staff does not have the necessary experience,
list
experts at your institution who can provide training. Your IACUC
will have to verify that this training took place before animal work
can
begin.
- Endpoint criteria. Choose endpoints that achieve
the aims of the study and avoid unnecessary pain and distress.
Include
the criteria
you will use to decide when to intervene or end animal use in the
study, e.g., pain that cannot be controlled with analgesics,
tumor size, and stage of disease. Interventions include euthanasia,
treatment, or discontinuance of procedure. Many institutions have
default
criteria,
so check with
your IACUC for guidance.
Also see Working with the IACUC: Writing an Animal Protocol,
a booklet published by the American Association for Laboratory Animal Science,
for help preparing your animal protocol as well as interacting with
an IACUC.
Resources
Write
the Application: Indicate Use of Animals
If you're using research animals, you'll need to answer the question "Vertebrate animals, yes or no" in Item 5 on the face page of the PHS 398 (for paper applications) or in Item 2 of the Other Project Information component in your Grant Application Package (for electronic applications).
Remember that your application covers all performance sites, including subaward partners, collaborators, and others involved in the research.
Even if the animal work will be done somewhere other than your institution,
mark "yes."
For paper applications, follow the instructions for Vertebrate Animals in the PHS 398. For electronic applications, follow the instructions for Vertebrate Animals in the Grant Application Guide.
Go to Other Project Information Form: Facilities, Resources, and Equipment in the NIH Grant Cycle: Application to Renewal for a brief description of what you need to put in the application.
To see if your institution or performance site is assured, check Domestic Institutions
with a PHS Approved Animal Welfare Assurance or Foreign Institutions
with a PHS Approved Animal Welfare Assurance.
Resources
Answer
the Five Points in the Vertebrate Animals Section
Peer
reviewers can adjust
your priority
score based on your responses to the five points in the Vertebrate
Animals Section of the Research
Plan.
- Provide a detailed description of the use of animals in the work
previously outlined in the experimental design and methods section.
Identify species, strains, ages, sex, and numbers of animals to be
used.
- Justify the use of animals, choice of species, and numbers used.
If animals are in short supply, costly, or to be used in large numbers,
provide additional rationale for their selection and numbers.
- Provide information on veterinary care.
- Describe procedures for ensuring that discomfort, distress, pain,
and injury will be limited to that which is unavoidable to conduct
scientifically sound research. Describe the use of analgesic, anesthetic,
and tranquilizing drugs and comfortable restraining devices, where
appropriate, to minimize discomfort, distress, pain, and injury.
- Describe any euthanasia method to be used and the reasons for its
selection. State whether this method is consistent with the recommendations
of the Panel on Euthanasia of the
American Veterinary Medical Association.
If not, present a justification for not following the recommendations.
For electronic applications, follow the instructions for Vertebrate Animals in the Grant Application Guide. For paper applications, follow the instructions for Vertebrate Animals in the PHS 398.
Since there is no page limit for this section, use as much space as
you need to convince reviewers that you'll do everything right. Don't
assume reviewers will automatically know what you're talking about.
Help them understand why your approach will yield the best results
and how you will limit animal pain and distress to that which is scientifically
necessary.
See Part 5. Research Plan and Part 6. Other Application Sections in the NIH
Grant Cycle: Application to Renewal for more advice on drafting
your application.
Resources
How NIAID Reviews Applications Using Research Animals
When
assessing the scientific merit of an application, all NIH initial
peer review committees use the same review
criteria. For information on NIH review criteria, read How NIH Review Criteria Affect Your Score.
Peer
reviewers also evaluate your project's compliance with federal
requirements for animal research, rating your application
based on your responses to the five points in the Vertebrate Animals
Section. Any problems may negatively affect your priority score.
Resources
Understand
Codes on Your Summary Statement
SROs will code your summary
statement to reflect your use of research animals. Such codes
can also indicate assurance status,
need for IACUC review, missing information, reviewer concerns, or the
fact
that there
are no problems
and NIAID can
issue
your award.
See Research Animals
Involvement Codes for a complete list.
Codes that result in a bar
to award must be resolved before NIAID can release your award.
If your summary
statement lists such a code, contact the program officer listed
on your summary statement right away.
Resources
NIAID
Will Send a Just-in-time Request
After
you've cleared initial
peer review and resolved any reviewer concerns,
we'll send
you a request for just-in-time information
if your application is in the fundable range.
For animal research, you will need to send in your certification
of IACUC approval before NIAID can issue your award. See If You
Have Animal Research Documentation and Prepare Your Just-in-Time Information in the NIH Grant Cycle: Application to Renewal.
Resources
Reporting
Requirements During Your Award
During the life of your grant, there are several reporting requirements
NIAID requires. For example, you'll need to get your certification
of IACUC approval at least every three years.
For general reporting requirements, start reading at Your Reporting Requirements in the NIH Grant Cycle: Application to Renewal.
Resources
IACUCs
Monitor Your Progress
By
signing your application, your institutional
official promises
the federal government that your institution will comply with all terms
and conditions of award, including those covering animal care
and use. Monitor your work closely. As PI,
you are accountable for all activities involving animals during
the project.
Your approved animal use protocol is
a contract between you and your IACUC,
stipulating that your project will follow all institutional polices
and procedures. You must obtain IACUC approval before you make
any significant changes to the research, including the following.
- Study objectives.
- Non-survival to survival surgery.
- Species or number of animals.
- Invasiveness of a procedure.
- Use of anesthetics or analgesics.
- Methods of euthanasia.
- Change in PI.
The definition of a "significant change" varies from institution to
institution, so consult your IACUC for guidance. In a recent policy
shift, NIH allows IACUCs to classify personnel changes other than PI
as minor, provided the IACUC ensures that staff are trained and qualified.
If you're planning
to make a significant change to your project, also contact your program
officer right away. The NIH
Grants Policy Statement requires grantees to obtain prior
approval from NIH for changes in scope. For a list, see Some Actions
Require Our Approval in the NIH Grant Cycle: Application to Renewal.
You will also need to get a new IACUC approval every three years;
some IACUCs may require it sooner. Institutional officials and IACUCs
do not have authority to extend an IACUC approval beyond its expiration
date. Conducting research in the absence of a valid IACUC approval
constitutes noncompliance with PHS policy
and it is reportable to OLAW.
Resources
You'll
Have Semiannual Reviews and Inspections
As
part of its semiannual program review and facility inspection, your IACUC will
conduct routine assessments of institutional animal activities.
This review covers institutional policies and responsibilities, IACUC
membership and functions, and IACUC record keeping and reporting procedures.
It also looks at the adequacy and appropriateness of animal environment, housing, and management; veterinary care;
staff training; emergency preparedness; and occupational health and safety programs.
A facility review is a physical inspection of buildings, areas, and
vehicles (including satellite facilities housing animals for more than
24 hours) used for confinement, transport, maintenance, breeding, or
experiments, including surgery.
Your lab may be inspected as part of a facility review, or your IACUC
may randomly visit to verify that you are following your protocol.
IACUCs report the results of their program evaluation and facility
inspection to the institutional
official for animal welfare. These reports describe any deficiencies
found and include plans and schedules for correcting each one.
Institutional officials submit semiannual IACUC reports to OLAW only
if requested or if the institution is submitting a new or renewal animal
welfare assurance and is not accredited by the Association for Assessment and Accreditation of
Laboratory Animal Care.
Resources
Avoid
Suspension of Animal Activities
Your IACUC can
suspend your project if it finds serious or continuing noncompliance
with PHS policy
or your institution's assurance or
deviations from the approved protocol or
the Guide
for the Care and Use of Laboratory Animals.
If you have a subaward agreement, noncompliance at the subaward organization can also provoke a suspension. See the Subawards for Grants SOP for more information.
Your IACUC will convey its reasons for a suspension to the institutional
official for animal welfare, who will take corrective measures
and report the situation to OLAW.
OLAW can withdraw approval of your institution's assurance,
though this is extremely rare. Should this happen,
your institution would become ineligible for spending NIH funds on research activities involving
animals, and
NIAID may seek to recover its monies. NIH may allow expenditures for the maintenance and care of animals.
OLAW can also place restrictions on an institution's assurance until
compliance problems are fully resolved. OLAW always emphasizes corrective
rather than punitive actions and will only restrict or withdraw approval
of an assurance if an institution's efforts to correct its problems
are unsuccessful.
Resources
Know
Your IACUC's Reporting Requirements
At
least once every 12 months your institution is required to
submit a report to OLAW,
signed by the institutional
official for animal welfare and institutional
animal care and use committee (IACUC) chairperson. The report
includes the following.
OLAW now strongly encourages institutions
to send in their annual reports by December 31.
Your institutional official for animal welfare must notify OLAW's
Division of Compliance promptly at 301-496-7163 of any of the following.
Your institution sends annual reports as well as follow-up reports
of noncompliance, deviations, and IACUC suspensions to:
Office of Laboratory Animal Welfare
RKL1, Suite 360, MSC 7982
6705 Rockledge Drive
Bethesda, MD 20892-7982 (Use this ZIP code for the U.S. Postal Service, including express mail.)
Bethesda, MD 20817 (Use this ZIP code for commercial carriers such as FedEx and UPS.)
Resources
Keep
Your Records Accessible
You must keep your project records accessible for three years after
the grant ends. If an issue arises, NIAID must be able to verify the
records, which must include all data and fiscal information.
Under PHS policy your institution is
required to maintain the following records for a minimum of three years:
- Assurance approved by the Office
of Laboratory Animal Welfare.
- Minutes of IACUC meetings.
- Records of IACUC activities and deliberations.
- Minority IACUC views.
- Documentation of protocols reviewed by the IACUC, and proposed
significant changes to protocols (this documentation must be maintained
for an additional three years after completion of animal activities).
- IACUC semiannual program evaluations and facility inspections,
including deficiencies identified and plans for correction.
- Accrediting body determinations.
Through the Freedom of Information Act, the public
can access information about your grant. If someone formally requests
non-proprietary information about your application, our FOIA office
will provide it.
Resources
In
Conclusion
We
hope these pages have helped you. If you're looking for more in-depth
information, please refer to Basic
resources for applications involving animals. If you have questions
that weren't answered here, please contact OLAW or Contact Staff for Help.
This site is part of NIAID's outreach to its extramural research community. Let us know how you liked the site and what other information
or resources you'd like to see online by emailing deaweb@niaid.nih.gov.
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