NATIONAL INSTITUTES OF HEALTH SEARCH THIS SITE

Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Principal Investigators Daniel R. Weinberger, M.D.   Dr. Weinberger is chief of the Clinical Brain Disorders Branch of the Intramural Research Program, National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland. He attended college at the Johns Hopkins University and medical school at the University of Pennsylvania and did residencies in psychiatry at Harvard Medical School and in neurology at George Washington University. He is board certified in both psychiatry and neurology. He is past president of the Society of Biological Psychiatry and a member of the Institute of Medicine of the National Academy of Sciences. Research Interests Dr. Weinberger's laboratory studies basic mechanisms of pathogenesis of major psychiatric illness, especially schizophrenia. His group is interesting in characterizing the genetic mechanisms of susceptibility, studying individual gene effects on brain information processing in patients, in normal volunteers, across the aging cycle, and in animal models. The lab pursues translational projects ranging from genetic engineering in animals, to gene expression and regulation in cell systems and in human brain tissue, to studies of brain function with neuroimaging in living subjects, stratified by relevant genotype. His lab has identified the first specific genetic mechanism of risk for schizophrenia, and the first genetic effects that account for variation in specific human cognitive functions. In addition, he and his colleagues developed the first high fidelity animal model of schizophrenia. Representative Selected Recent Publications: Weinberger DR, McClure RK: Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: What is happening in the schizophrenic brain? Arch Gen Psychiatry, 59:553-558, 2002. Weinberger DR, Egan MF, Bertolino A, Callicott JH, Mattay VS, Lipska BK, Berman KF, Goldberg TE: Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 50:825-844, 2001. Hariri A, Mattay VS, Tessitore A, Kolachaqna B, Fera F, Goldman, D, Egan MF, Weinberger DR: Serotonin transporter genetic variation and the response of the human amygdala. Science, 297: 400-404, 2002. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR: effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. PNAS 98:6917-6922, 2001. Lipska BK, Halim ND, Segal PN, Weinberger DR: Effects of reversible inactivation of the neonatal ventral hippocampus on behavior in the adult rat. J Neurosci, 22:2835-2842, 2002. Address:   Phone:   Email Fax:   Lab Web Site: http://cbdb.nimh.nih.gov/     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Staff Scientists/Clinicians Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Non-Human Primate Core Scientific and Statistical Computing Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

This page was last updated January 13, 2009   Site Map Subscribe Staff Directories Contact NIMH DIRP Employment Opportunities Copyright Policies FOIA

The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.