| | Principal Investigators
| Dennis L. Murphy, M.D. |
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|
Dr.
Murphy is the Chief of the Laboratory
of Clinical Science in the National Institute
of Mental Health Intramural Research Program. He received
his undergraduate and medical degrees from Marquette University
and completed his internship and residency programs at
the University of Minnesota and Johns Hopkins University.
He has received awards for his research, serves on the
editorial boards of neuroscience and pharmacology journals,
and is on the Advisory Boards of Associations and Foundations. |
| Research Interests |
| The
Laboratory of Clinical Science (LCS) explores the neurobiology
of neuropsychiatric disorders using molecular, neurochemical
and genetic techniques. Its present focus links studies
of transgenic mice with clinical brain disorders using
gene-environment interaction models. The serotonin neurotransmitter
system and one of its key molecules, the serotonin transporter
(SERT) is the primary target of LCS research. The development
of the SERT knockout mouse in the LCS provided a new living
tool to discover what the serotonin system does, as SERT
and serotonin receptors are the target molecules for the
largest numbers of neuropsychiatric drugs used in the
world. The 30 plus neurochemical, behavioral and other
phenotypic changes discovered in the serotonin knockout
mouse are helping to guide the LCS and other laboratories
in investigations of the more than 10 variants recently
discovered in the human SERT gene. |
| Representative Selected Recent Publications: |
- Murphy DL, Lesch KP:
Targeting the murine serotonin transporter:insights into human neurobiology.
Nat Rev Neurosci, 9:85-96, 2008.
- Wendland JR, Moya PR, Kruse MR, Ren-Patterson RF, Jensen CL, Cromer KR, Murphy DL:
A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder.
Hum Mol Genet., 17:717-23, 2008.
- Fox MA, Jensen CL, Gallagher PS, Murphy DL:
Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice.
Neuropharmacology., 53:643-56, 2007.
- Ren-Patterson RF, Cochran LW, Holmes A, Lesch K-P, Lu B, Murphy DL:
Gender-Dependent Modulation of Brain Monoamines and Anxiety-like Behaviors in Mice with Genetic Serotonin Transporter and BDNF Deficiencies.
Julius Axelrod Memorial Issue: Cell Mol Neurobiol., 26:755-78, 2006.
- Wendland JR, Martin BJ, Kruse MR, Lesch KP, Murphy DL:
Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531.
Mol Psychiatry., 11:224-6, 2006.
- Li Q, Holmes A, Ma L, Van de Kar Louis D, Garcia F, Murphy DL:
Medial Hypothalamic 5-Hydroxytryptamine (5-HT)1A Receptors Regulate Neuroendocrine Responses to Stress and Exploratory Locomotor Activity: Application of Recombinant Adenovirus Containing 5-HT1A Sequences.
J Neurosci, 2004, 24:10868-10877.
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