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Transforming the understanding and treatment of mental illness through research
DIVISION OF INTRAMURAL RESEARCH PROGRAMS
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 Principal Investigators

Maribeth V. Eiden, Ph.D.
Dr. Eiden Photo   Dr. Eiden is chief of the Section on Molecular Virology in the NIMH Intramural Research Program (IRP). She received her undergraduate degree in microbiology at the University of Maryland, her doctoral degree in genetics at George Washington University, and joined the Laboratory of Cell Biology (now the Laboratory of Cellular and Molecular Regulation) in 1986.

Dr. Eiden serves on the review board of Journal of Virology, is chairman of the NIH Intramural Biosafety Committee and is as a member of NIAID Virology Study Section.
Research Interests
The Section on Molecular Virology expects to consolidate progress in virus-mediated gene delivery, especially in its application to gene transfer into fully differentiated cells, and to determine critical post-binding steps in viral entry exploitable for gene therapeutic application. The study of emerging viruses, and the role of viral envelope/receptor interactions in host range and pathogenicity, is an important new focus of the group.

Dr. Eiden’s group is using the GALV receptor/phosphate transporter as a model for integral membrane biogenesis of a polytopic protein. Her laboratory has determined that a region of the GALV receptor previously assumed to function as the virus attachment site functions instead as a topogenic determinant regulating the membrane integration of this cell surface protein. She also has embarked on the study of GALV as a model for emerging infections in other mammalian species. Evidence of GALV’s ability to jump species has been most recently observed in koalas where it is implicated in leukemias and lymphomas and in immunosuppression within this marsupial population.
Representative Selected Recent Publications:
  • Gemeniano M, Mpanju O, Salomon DR, Eiden MV, Wilson CA: The infectivity and host range of the ecotropic porcine endogenous retrovirus, PERV-C, is modulated by residues in the C-terminal region of its surface envelope protein. Virology, 2006, in press.
  • Farrell KB, Eiden MB: Dissection of gammaretroviral receptor function by using type III phosphate transporters as models. Journal of Virology, 79: 9332-9336, 2005. (View PDF)
  • Wang W, Jobbagy Z, Bird TH, Eiden MV, Anderson WB: Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced synctium formation. Journal Biological Chemistry, 280: 16772-16782, 2005. (View PDF)
  • Feldman SA, Farrell KB, Murthy RK, Russ JL, Eiden MB: Identification of an extracellular domain within the human PiT2 receptor that is required for amphotropic murine leukemia virus binding. Journal of Virology, 78: 595-602, 2004. (View PDF)
  • Khadeer MA, Tang Z, Tenenhouse HS, Eiden MV, Murer H, Hernando N, Weinman EJ, Chellaiah MA, Gupta A: Na+-dependent phosphate transporters in the murine osteoclast: cellular distribution and protein interactions. American Journal of Physiology, Cell Physiology, 284: C1633-44, 2003. (View PDF)
  • Faix, P.H., S. A. Feldman, J. Overbaugh, and M. V. Eiden: Host range and receptor binding properties of vectors bearing Feline Leukemia virus subgroup B envelopes is modulated by envelope sequences outside of the receptor binding domain. Journal of Virology 76:12369-12375, 2002. (View PDF)

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Phone: (301) 435-7522 (office), (301) 435-7523 (laboratory)
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Lab Web Site: http://intramural.nimh.nih.gov/lcmr/
   
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This page was last updated January 13 2009


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