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Transforming the understanding and treatment of mental illness through research DIVISION OF INTRAMURAL RESEARCH PROGRAMS

Principal Investigators Peter J. Schmidt, M.D.   Dr. Schmidt graduated with honors from the Royal College of Surgeons in Ireland with MB and BCh degrees. His medical internship and psychiatry residency were completed at the University of Toronto, Canada. Upon completing his psychiatric residency, Dr. Schmidt joined the NIMH as an Ontario Mental Health Foundation Fellow. His laboratory is interested in the neurobehavioral effects of gonadal steroids in humans, including the roles of gonadal steroids in mood state regulation in women with menstrual-related mood disorders, perimenopause-related depression and puerperal depression. Research Interests The research in this group has the following foci: 1) the characterization of affective disorders occurring during the perimenopause; 2) the identification of the role of gonadal steroids in perimenopause-related depression, menstrual-related mood disorder, and puerperal depression; 3) the examination of the neuroregulatory consequences of the presence and absence of gonadal steroids; 4) the characterization of the interaction between the aging process and the effects of gonadal steroids on CNS function. Representative Selected Recent Publications: Schmidt, P.J., Murphy, J.H., Haq, N., Danaceau, M.A., Simpson-St. Clair, L.: Basal plasma hormone levels in depressed perimenopausal women. Psychoneuroendocrinology, 2002. Bloch, M., Schmidt, P.J., Danaceau, M.A., Murphy, J.H., Nieman, L.K., Rubinow, D.R.: Effects of gonadal steroids in women with a history of postpartum depression, American Journal of Psychiatry 157, 924-930, 2000. Schmidt, P.J., Nieman, L., Danaceau, M.A., Tobin, M.B., Roca, C.A., Murphy, J.H., Rubinow, D.R.: Estrogen replacement therapy in perimenopause-related depression: a preliminary report, American Journal of Obstetrics and Gynecology 183, 414-420, 2000. Bloch, M., Schmidt, P.J., Danaceau, M.A., Adams, L.F., Rubinow, D.R.: Dehydroepiandrosterone treatment of mid-life dysthymia, Biological Psychiatry 45, 1533-1541, 1999. Schmidt, P.J., Nieman, L.K., Danaceau, M.A., Adams, L.F., Rubinow, D.R. Differential behavioral effects of gonadal steroids in women with and in those without premenstrual syndrome, New England Journal of Medicine 338, 209-216. 1998. Address:   Phone:   Email: Fax:   Lab Web Site: http://intramural.nimh.nih.gov/beb/index2.htm     Principal Investigators Scientists & Clinicians DIRP Labs and Branches DIRP Research Areas Staff Scientists/Clinicians Office of the Scientific Director Site Map Participate in Research Contact Us Careers in Research What’s New Functional MRI Core Magnetic Resonance Core Magnetoencephalography Core Microarray Core Non-Human Primate Core Scientific and Statistical Computing Core Transgenic Core Veterinary Medicine Resources (Staff only) Office of the Scientific Director Office of the Clinical Director Office of Fellowship Training Office of Technology Transfer Administrative Services Branch Administrative Services

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The Division of Intramural Research Programs is within the National Institute of Mental Health (NIMH) is a part the National Institutes of Health (NIH), is a component of the U.S. Department of Health and Human Services.